PMID: 8071834May 1, 1994

Comparison of three new spectrophotometric methods for simultaneous determination of aspirin and salicylic acid in tablets without separation of pharmaceutical excipients

Journal of Pharmaceutical Sciences
B W Glombitza, P C Schmidt


Simultaneous analysis of aspirin (ASA) and salicylic acid (SA) in pharmaceutical tablet preparations was performed by two multicomponent UV-spectrophotometric methods utilizing principal component regression and classical least square algorithm. Additionally, an assay procedure based on second-derivative spectroscopy was developed. The analysis was performed in turbid solutions without separation of interfering excipients. The range, as determined by the second-derivative methods, was 0.2 to 103.2 micrograms/mL for ASA and 0.07 to 44.5 micrograms/mL for SA. Sensitivity for determination of SA was 0.004% of ASA content for the second-derivative method and 0.2% of ASA content for both multicomponent methods. The methods were applied to laboratory mixtures and commercial tablet formulations containing ASA and SA. The advantage of the second-derivative method in determining small amounts of SA in commercial tablet preparations is shown in comparison with a conventional HPLC method. All UV-spectrophotometric methods are rapid, accurate, and reproducible.


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Related Concepts

Process of Absorption
Drug Formulation Process
Pharmaceutical Excipient
Hydrogen-Ion Concentration
Salicylic Acids
Spectrophotometry, Ultraviolet

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