PMID: 2501280May 1, 1989Paper

Comparison of three tracers for detecting lung epithelial injury in anesthetized sheep

Journal of Applied Physiology
B T PetersonD B Holiday

Abstract

We compared the ability of three aerosolized tracers to discriminate among control, lung inflation with a positive end expired pressure of 10 cmH2O, lung vascular hypertension and edema without lung injury, and lung edema with lung injury due to intravenous oleic acid. The tracers were 99mTc-diethylenetriaminepentaacetate (99mTc-DTPA, mol wt 492), 99mTc-human serum albumin (99mTc-ALB, mol wt 69,000), and 99mTc-aggregated albumin (99mTc-AGG ALB, mol wt 383,000). 99mTc-DTPA clearance measurements were not able to discriminate lung injury from lung inflation. The 99mTc-AGG ALB clearance rate was unchanged by lung inflation and increased slightly with lung injury. The 99mTc-ALB clearance rate (0.06 +/- 0.02%/min) was unchanged by lung inflation (0.09 +/- 0.02%/min, P greater than 0.05) or 4 h of hypertension without injury (0.09 +/- 0.04%/min, P greater than 0.05). Deposition of 99mTc-ALB within 15 min of the administration of the oleic acid increased the clearance rate to 0.19 +/- 0.06%/min, which correlated well with the postmortem lung water volume (r = 0.92, P less than 0.01). This did not occur when there was a 60-min delay in the deposition of 99mTc-ALB. We conclude that 99mTc-ALB is the best indicator for studying the effect...Continue Reading

Citations

Feb 1, 1990·The American Review of Respiratory Disease·B T PetersonA B Cohen
Sep 1, 1994·Clinical Physiology·P Wollmer, E Evander
Mar 1, 1993·Experimental Lung Research·J C Connelly, B T Peterson
Jun 10, 2003·Journal of Applied Physiology·Clarke G TankersleyElizabeth M Wagner
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·H A GhofraniF Grimminger
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·John C LayWilliam D Bennett
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·William D Bennett

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