Comparison of three whole blood creatinine methods for estimation of glomerular filtration rate before radiographic contrast administration

American Journal of Clinical Pathology
Nichole L Korpi-SteinerBrad S Karon

Abstract

We compared the clinical concordance of estimated glomerular filtration rate (eGFR) based on 3 whole blood creatinine assays with the eGFR calculated from a reference plasma creatinine assay. Whole blood creatinine on the Radiometer ABL800 FLEX (Radiometer A/S, Bronshoj, Denmark) demonstrated the best correlation and concordance to plasma creatinine/eGFR compared with the i-STAT (i-STAT, East Windsor, NJ) and StatSensor (Nova Biomedical, Waltham, MA). The i-STAT had better sensitivity (compared with Radiometer) but poorer specificity for prediction of plasma eGFR less than 60 mL/min/1.73 m(2). The StatSensor demonstrated lower concordance of whole blood to plasma eGFR but offered a slope and an intercept offset feature that partially compensates for this effect. The optimal device for use in rapid determination of eGFR from whole blood creatinine may depend on whether it is more important in a given practice to optimize sensitivity, specificity, or overall concordance for determining plasma eGFR less than 60 mL/min/1.73 m(2).

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Citations

Feb 27, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Céline L van LintChrista M Cobbaert
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Felipe Martínez Lomakin, Catalina Tobar
May 21, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Lauren E GalbraithBrenda R Hemmelgarn
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Sara A LovePrasad V A Pamidi
Mar 25, 2020·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Jacqueline DonovanRoss T Tsuyuki
Jun 8, 2017·Experimental and Therapeutic Medicine·Akitoshi InoueKiyoshi Murata
Jun 24, 2017·Journal of the American Medical Informatics Association : JAMIA·Ronald G HauserSheldon Campbell
Sep 26, 2020·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Daniel FitzpatrickLuke Hodgson

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