Abstract
Unlike in western countries, premixed insulin is widely used as the starter insulin in Asian patients instead of basal insulin. The use of basal-bolus therapy as an intensification regimen is not common in Asia despite poor glycaemic control after starting insulin therapy. An alternative insulin intensification regimen with a similar efficacy and safety profile to basal-bolus therapy, but of higher convenience, is urgently needed. The efficacy and safety of insulin lispro mix thrice-daily was compared with basal-bolus therapy in Asian patients with type 2 diabetes who were insufficiently controlled on twice-daily premixed insulin. This open-label, randomised, active comparator-controlled, parallel-group trial was done at 24 centres in China, Taiwan, and South Korea. Patients with type 2 diabetes who were inadequately controlled on twice-daily premixed insulin were randomly assigned (1:1) to receive either insulin lispro mix (mix 50 before breakfast and lunch plus mix 25 before dinner) or basal-bolus therapy (insulin glargine at bedtime plus prandial insulin lispro thrice-daily) for 24 weeks. Randomisation was done by a computer-generated random sequence and was stratified by country or region and baseline HbA1c. Treatment assig...Continue Reading
References
Jul 1, 1997·Diabetes Care
Mar 31, 1998·Journal of Pharmaceutical Sciences·M R DeFelippisB H Frank
May 20, 1998·Diabetes Care·T HeiseL Heinemann
Aug 8, 1998·BMJ : British Medical Journal
Dec 16, 2000·Diabetes·M LeporeG B Bolli
Jan 11, 2001·Diabetologia·Q QiaoUNKNOWN DECODA Study Group
Sep 27, 2002·The Korean Journal of Internal Medicine·Sang Guk KimMin Young Chung
Oct 31, 2002·Clinical Pharmacokinetics·Paris Roach, James R Woodworth
Oct 16, 2007·Diabetes Care·Julio RosenstockSherry Martin
Feb 13, 2009·Current Medical Research and Opinion·Changyu PanHui Tian
Jun 3, 2009·Diabetes Care·Tim HeiseKlaus J Olsen
Sep 19, 2009·Current Medical Research and Opinion·Marcus HompeschScott J Jacober
Jan 28, 2010·Diabetes Care·Mark PeyrotLuther B Travis
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Oct 27, 2011·Diabetes Care·Matthew RiddleJulio Rosenstock
Nov 17, 2011·Statistics in Medicine·Yongming QuWalter Offen
Mar 28, 2012·Current Medical Research and Opinion·Wenying YangHaoming Tian
Jun 26, 2012·Diabetes, Obesity & Metabolism·M PeyrotP-M Schumm-Draeger
Sep 22, 2012·Diabetes Care·Andrea GiaccariSimona Frontoni
Jun 27, 2013·BMC Public Health·Li-Nong JiYan-Cheng Xu
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Citations
Aug 19, 2015·Endocrine·Dario GiuglianoKatherine Esposito
Feb 4, 2016·Journal of Diabetes Research·Feng-Fei LiJian-Hua Ma
Sep 10, 2015·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sanjay Kalra, Yashdeep Gupta
Feb 15, 2013·Journal of the Science of Food and Agriculture·Zhenzhu XuJunye Zhao
Mar 24, 2016·Endocrine·Maria Ida MaiorinoDario Giugliano
Apr 30, 2016·Current Medical Research and Opinion·D GiuglianoR Gentilella
Sep 24, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Michelle DownieJencia Wong
Oct 4, 2016·Clinical Pharmacokinetics·Hanne HaahrTim Heise
Jun 12, 2016·Journal of Diabetes Investigation·Wei ChenWen Ying Yang
Dec 19, 2016·Diabetes & Metabolism·A J ScheenT Ivanyi
Dec 9, 2016·Journal of Diabetes Investigation·Wayne H-H SheuThomas Lew
Apr 15, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Riccardo CandidoEster Romoli
Oct 27, 2017·Current Medical Research and Opinion·Ignacio CongetDavid M Kendall
Aug 11, 2018·Diabetes Technology & Therapeutics·Di SunXiu-Xin Hou
May 26, 2017·Diabetes & Metabolism Journal·Sung Hee ChoiHak Chul Jang
Sep 30, 2018·Science China. Life Sciences·Zekai WuJianping Weng
Oct 5, 2018·BMC Endocrine Disorders·Jing LiLingling Miao
Feb 25, 2020·Journal of Diabetes Research·Bing-Li LiuFeng-Fei Li
Jul 2, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Li Xin ShiJia Ning Hou
Apr 26, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Takahisa HiroseJacek Kiljański
Apr 8, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Ting HongYan Bi
Aug 24, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Feng-Fei LiJian-Hua Ma
Nov 20, 2016·Diabetes Technology & Therapeutics·Abraham Edgar Gracia-RamosJosé Leopoldo Aguilar-Faisal
Nov 26, 2020·Diabetes, Obesity & Metabolism·Christoph KapitzaIrene Nowotny