Comparison of ticlopidine vs. clopidogrel in addition to aspirin after paclitaxel-eluting stent implantation: insights from the TRUE (Taxusin Real-life Usage Evaluation) Study

International Journal of Cardiology
Giuseppe G L Biondi-ZoccaiTRUE (Taxus in Real-Life Usage Evaluation) Study Investigators

Abstract

Thienopyridines and aspirin are beneficial in patients undergoing bare-metal stent implantation, and aspirin and clopidogrel treatment have also been proved effective after drug-eluting stent (DES) implantation. However, despite the common substitution of clopidogrel with ticlopidine because of cost or patient intolerance, there are no data on the comparison of ticlopidine vs. clopidogrel after DES implantation. We hereby compare ticlopidine vs. clopidogrel after paclitaxel-eluting stent implantation in subjects enrolled in the prospective multicenter Taxus in Real-life Usage Evaluation (TRUE) Study. Across the 505 analyzed patients (112 treated with ticlopidine and 393 with clopidogrel), similar rates of early and mid-term (7 months) adverse thrombotic events were found with either antiplatelet regimen, with the notable exception of 2 cases of late stent thrombosis in patients who had prematurely withdrawn ticlopidine treatment just 3 months after the procedure. These findings thus support the overall safety and effectiveness of ticlopidine after DES implantation, and also confirm the increased risk of late thrombosis when premature withdrawal of thienopyridines occurs.

Citations

Aug 2, 2008·Current Opinion in Cardiology·Marzia Lotrionte, Giuseppe Gl Biondi-Zoccai
Jan 31, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Craig S McLachlanShu-Hui Chia
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Jan 30, 2008·Pharmacotherapy·Phillip OwenRobert Lee Page
Jun 10, 2015·Drugs·Craig J BeaversKathryn M Ruf
Sep 11, 2010·International Journal of Cardiology·Giuseppe Biondi-ZoccaiImad Sheiban
Dec 17, 2010·World Journal of Cardiology·Giuseppe Biondi-ZoccaiFiorenzo Gaita
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Jun 9, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·F W A VerheugtR -J M van Geuns

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