Comparison of Time to First Dose of Oral Morphine in the Treatment of Neonatal Abstinence Syndrome

Pharmacotherapy
Sarah T MitchellKara M Nedderman

Abstract

To compare time to first dose of oral morphine used in the treatment of neonatal abstinence syndrome (NAS) in a neonatal intensive care unit (NICU) versus a special care nursery (SCN) setting. A retrospective chart review was completed of patient data from two community hospitals in a single health network. Infants born at either facility between January 2013 and August 2015 were eligible for inclusion in the study if treated for NAS with a course of oral morphine. The primary outcome was time from birth to first dose of oral morphine. Secondary outcomes included details about the morphine treatment course, length of stay, and complications from NAS. A total of 54 patients (19 NICU patients and 35 SCN patients) fulfilled inclusion criteria for the study. The primary outcome of median time from birth to first dose of oral morphine did not differ between the two groups (42.5 hrs [NICU] vs 43 hrs [SCN], p=0.53). No significant differences were found between the morphine regimens used in the two units. The median length of hospital stay (27 days [NICU] vs 26 days [SCN], p=0.66) and median length of NICU/SCN stay (26 days [NICU] vs 23 days [SCN], p=0.75) were not statistically significantly different. Time between transfer to the NI...Continue Reading

References

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Nov 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mallory E YoungDarrell Spurlock

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Citations

Jul 21, 2017·Pharmacotherapy·C Lindsay DeVane

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