Comparison of tissue and molecular yield between fine-needle biopsy (FNB) and fine-needle aspiration (FNA): a randomized study

Endoscopy International Open
Ravishankar AsokkumarRoy Soetikno

Abstract

Background and study aims  Recently, a new Franseen design endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle was developed with the goal of providing more tissue for histology. We compared the tissue adequacy rate and nucleic acid yield of 22G EUS-FNB vs. 22G endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), in solid gastrointestinal and extra-intestinal lesions. Patients and methods  We conducted a randomized crossover study and recruited 36 patients. We performed three passes for pancreatic lesions and two passes for other lesions, using each needle. We blinded the pathologist to needle assignment. We assessed the diagnostic tissue adequacy rate and compared the total tissue area, diagnostic tissue area, and desmoplastic stroma (DS) area in cases of carcinoma. We also examined the nucleic acid yield of the two needles in pancreatic lesions. Results  The lesions included 20 pancreatic masses (55 %), six gastric subepithelial lesions (17 %), five lymph nodes (14 %) and five other abdominal masses (14 %). Mean ± SD lesion size was 3.8 ± 2.0 cm. The final diagnosis was malignant in 27 lesions (75 %) and benign in nine lesions (25 %). We found EUS-FNB procured significantly more median total tissue area...Continue Reading

Citations

May 30, 2020·Diagnostics·Robert DorrellRishi Pawa
Oct 6, 2020·Endoscopy International Open·Benedetto MangiavillanoAlessandro Repici
Jan 28, 2021·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·José Celso ArdenghJosé Sebastião Dos Santos
Oct 23, 2020·World Journal of Gastroenterology : WJG·Petros StathopoulosUlrike Walburga Denzer
Jul 19, 2020·Journal of the American Society of Cytopathology : JASC·Amin K Soltani, Kumar Krishnan
Jun 4, 2021·Endoscopy International Open·Samuel HanUNKNOWN Collaborative Alliance for Pancreatic Education and Research (CAPER)
Jul 31, 2021·World Journal of Gastroenterology : WJG·Irving Levine, Arvind J Trindade

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Methods Mentioned

BETA
biopsy
sedation

Clinical Trials Mentioned

NCT03109639

Software Mentioned

R Core Team
R
IntelliSite Pathology

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