Comparison of tolerability and adverse symptoms in oxcarbazepine and carbamazepine in the treatment of trigeminal neuralgia and neuralgiform headaches using the Liverpool Adverse Events Profile (AEP)

The Journal of Headache and Pain
E BesiJ M Zakrzewska

Abstract

Adverse effects of drugs are poorly reported in the literature . The aim of this study was to examine the frequency of the adverse events of antiepileptic drugs (AEDs), in particular carbamazepine (CBZ) and oxcarbazepine (OXC) in patients with neuralgiform pain using the psychometrically tested Liverpool Adverse Events Profile (AEP) and provide clinicians with guidance as to when to change management. The study was conducted as a clinical prospective observational exploratory survey of 161 patients with idiopathic trigeminal neuralgia and its variants of whom 79 were on montherapy who attended a specialist clinic in a London teaching hospital over a period of 2 years. At each consultation they completed the AEP questionnaire which provides scores of 19-76 with toxic levels being considered as scores >45. The most common significant side effects were: tiredness 31.3 %, sleepiness 18.2 %, memory problems 22.7 %, disturbed sleep 14.1 %, difficulty concentrating and unsteadiness 11.6 %. Females reported significantly more side effects than males. Potential toxic dose for females is approximately 1200 mg of OXC and 800 mg of CBZ and1800mg of OXC and 1200 mg of CBZ for males. CBZ and OXC are associated with cognitive impairment. Phar...Continue Reading

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Citations

Jun 22, 2016·Neurosurgery Clinics of North America·Joanna M Zakrzewska, Clare Relton
Jan 24, 2017·Pain·Joanna M ZakrzewskaSue H Pavitt
Sep 30, 2017·American Journal of Physical Medicine & Rehabilitation·Dai ZhangYue Wen Ma
Jan 30, 2018·Acta Neurologica Scandinavica·V Tentolouris-PiperasR Cregg
Feb 15, 2018·The Clinical Journal of Pain·Joanna M ZakrzewskaYing Liu
Aug 4, 2018·CNS Drugs·Michael J Marmura, Aliza S Kumpinsky
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May 1, 2016·European Journal of Clinical Pharmacology·Jamil Poletti-JabbourCarmen Cecilia Elías-Barrera
Oct 15, 2019·Current Neuropharmacology·Erika Ivanna ArayaJuliana Geremias Chichorro
Jun 11, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·James W Edwards, Vivien Shaw
Jul 28, 2019·Current Medical Science·Yang-Pu ZhangAi-Qun Song
Sep 15, 2020·British Journal of Pain·Artemis GhiaiJoanna M Zakrzewska
Dec 5, 2017·The Cochrane Database of Systematic Reviews·Muke ZhouFengbo Wu
Aug 23, 2017·Expert Review of Neurotherapeutics·Giulia Di Stefano, Andrea Truini
Jul 19, 2020·The Journal of Headache and Pain·Rachel O CoatsMark Mon-Williams
Jul 17, 2020·Journal of Pain Research·Mona KotechaJoanna M Zakrzewska
Sep 29, 2020·NeuroRehabilitation·Sheryl D Katta-Charles
Mar 4, 2020·World Neurosurgery: X·Carolina Venda NovaRicheal Ni Riordain
Aug 31, 2020·European Annals of Otorhinolaryngology, Head and Neck Diseases·M-A LougesX Dubernard

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Stata
SPSS
Kinematic Assessment Tool ( KAT )

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