PMID: 108745Mar 29, 1979

Comparison of tolerance development and dependence capacities of morphine, beta-endorphin, and [D-Met2, Pro5]-enkephalinamide

E MigléczZ Dunai-Kovacs


The tolerance-development capacities of beta-endorphin, [D-Met2, Pro5]-enkephalinamide, and morphine were compared in rats, and the dependence capacity of morphine was compared with that of the enkephalin analogue in mice. Tolerance to the analgesic effect, as measured by the tail-flick test, developed somewhat more rapidly in the [D-Met2, Pro5]-enkephalinamide-treated group than in the others. A similar relationship was found for the dependence capacity. Considering that the enkephalin analogue displayed the strongest analgesic activity, the well-known correlation between antinociceptive and tolerance development/dependence capacities of opiates seems to be valid for opioid peptides as well.


Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H H LohC H Li
Jul 1, 1977·British Journal of Pharmacology·W Feldberg, D C Smyth
Jan 24, 1977·Biochemical and Biophysical Research Communications·L F TsengC H Li
Apr 1, 1977·Life Sciences·J I SzkelyL Gráf
Jun 1, 1977·European Journal of Pharmacology·J I SzékelyL Gráf
Jun 3, 1976·Nature·H H BuscherJ Pless
Sep 17, 1976·Science·A Goldstein
Sep 24, 1976·Science·E Wei, H H Loh
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C H Li, D Chung


Mar 26, 1985·European Journal of Pharmacology·M BroccardoP Melchiorri
Nov 5, 1979·Life Sciences·J SawynokF S LaBella
Feb 1, 1988·Neurochemical Research·L Rönnbäck, E Hansson
Nov 24, 2004·British Journal of Pharmacology·Yong BenNancy M Lee

Related Concepts

Drug Tolerance
Injections, Intraventricular
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Substance-Related Disorders
Mouse, Swiss

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