Comparison of Toxicities to Vibrio fischeri and Fish Based on Discrimination of Excess Toxicity from Baseline Level

PloS One
Xiao H WangYuan H Zhao

Abstract

Investigations on the relationship of toxicities between species play an important role in the understanding of toxic mechanisms to environmental organisms. In this paper, the toxicity data of 949 chemicals to fish and 1470 chemicals to V. fischeri were used to investigate the modes of action (MOAs) between species. The results show that although there is a positive interspecies correlation, the relationship is poor. Analysis on the excess toxicity calculated from toxic ratios (TR) shows that many chemicals have close toxicities and share the same MOAs between the two species. Linear relationships between the toxicities and octanol/water partition coefficient (log KOW) for baseline and less inert compounds indicate that the internal critical concentrations (CBRs) approach a constant both to fish and V. fischeri for neutral hydrophobic compounds. These compounds share the same toxic mechanisms and bio-uptake processes between species. On the other hand, some hydrophilic compounds exhibit different toxic effects with greatly different log TR values between V. fischeri and fish species. These hydrophilic compounds were identified as reactive MOAs to V. fischeri, but not to fish. The interspecies correlation is improved by adding a...Continue Reading

References

Mar 27, 1998·Ecotoxicology and Environmental Safety·M T Cronin, T W Schultz
Aug 7, 2004·Environmental Science & Technology·Valérie MaederKonrad Hungerbühler
Aug 22, 2006·SAR and QSAR in Environmental Research·T W SchultzG D Veith
Nov 30, 2007·Environmental Science & Technology·Michiel T O Jonker, Stephan A Van der Heijden
Jun 28, 2008·Ecotoxicology and Environmental Safety·Marco VighiGianna Serafina Monti
Aug 3, 2010·The Science of the Total Environment·Xu J ZhangMichael H Abraham
Sep 8, 2010·SAR and QSAR in Environmental Research·W C QinM H Abraham
Mar 16, 2011·Chemical Reviews·Johannes A H SchwöbelMark T D Cronin
Jun 15, 2011·Environmental Science & Technology·Franziska SchrammGerrit Schüürmann
Sep 29, 2011·Environmental Science & Technology·David JonesSteven J Rowland
Apr 5, 2014·The Science of the Total Environment·Li M SuYuan H Zhao

❮ Previous
Next ❯

Citations

Mar 27, 2019·International Journal of Environmental Research and Public Health·Shengnan ZhangYuanhui Zhao
Jan 10, 2020·Environmental Science and Pollution Research International·Shengnan ZhangYuanhui Zhao
Oct 29, 2020·Environmental Science and Pollution Research International·Eun Hea JhoJoo-Won Nam

❮ Previous
Next ❯

Software Mentioned

EPI Suite
Minitab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.