Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease.

World Journal of Gastroenterology : WJG
Hong-Hui WangHui-Xiang Yang

Abstract

To observe gene polymorphisms of TPMT and NUDT15, and compare their predictive value for azathioprine (AZA)-induced leukopenia in inflammatory bowel disease (IBD). This study enrolled 219 patients diagnosed with IBD in Xiangya Hospital, Central South University, Changsha, China from February 2016 to November 2017. Peripheral blood of all patients was collected to detect their genotypes of TPMT and NUDT15 by pyrosequencing at the Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital. Eighty patients were treated with AZA according to the disease condition. During the first month, patients who received AZA underwent routine blood tests and liver function tests once a week. The endpoint of the study was leukopenia induced by AZA. By analyzing patient characteristics, genotypes and leukopenia induced by drug use, we found the risk factors associated with AZA-induced leukopenia. There were 219 patients with IBD (160 men and 59 women), including 39 who were confirmed with ulcerative colitis (UC), 176 with Crohn's disease (CD) and 4 with undetermined IBD (UIBD). There were 44 patients (20.1%) with mutant genotype of NUDT15 (C/T); among them, 16 received AZA, and 8 (50%) developed leukopenia. T...Continue Reading

References

Sep 15, 2009·World Journal of Gastroenterology : WJG·Peter Laszlo Lakatos
Feb 24, 2010·Journal of Clinical Pharmacy and Therapeutics·M GazouliE Roma-Giannikou
Feb 22, 2012·La Presse médicale·Claire Le Jeunne
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Apr 5, 2013·World Journal of Gastroenterology : WJG·Florian BärKlaus Fellermann
Apr 16, 2013·Gastroenterology·Siew C NgUNKNOWN Asia–Pacific Crohn's and Colitis Epidemiologic Study (ACCESS) Study Group
Jul 2, 2015·Intestinal research·Kang-Moon LeeUNKNOWN IBD Study Group of the Korean Association for the Study of Intestinal Diseases
Feb 16, 2016·Nature Genetics·Takaya MoriyamaJun J Yang
Oct 16, 2016·Journal of Clinical Gastroenterology·Charles N BernsteinUNKNOWN Review Team:
Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Berrie MeijerNanne K H de Boer

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Citations

Jul 26, 2019·Alimentary Pharmacology & Therapeutics·Sara van GennepNanne K H de Boer
Feb 6, 2019·Therapeutic Advances in Gastroenterology·Xiao Jing Iris Wang, Michael Camilleri
Aug 28, 2020·Acta Clinica Belgica·Wautier SéverineCoche Jean-Charles
Mar 7, 2021·Clinical Biochemistry·Ann M Moyer
Aug 3, 2021·Frontiers in Medicine·Carla J Gargallo-PuyueloFernando Gomollón
Dec 21, 2021·Frontiers in Pharmacology·Kanyarat KhaesoNathorn Chaiyakunapruk

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Methods Mentioned

BETA
biopsy
Assay

Software Mentioned

SPSS
PrimerQuest Tool
PyroMark Assay Design

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