Comparison of tracheal reconstruction with allograft, fresh xenograft and artificial trachea scaffold in a rabbit model

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Jae Yeon LeeDong-Woo Cho

Abstract

This study evaluated the possibility of tracheal reconstruction with allograft, pig-to-rabbit fresh xenograft or use of a tissue-engineered trachea, and compared acute rejection of three different transplanted tracheal segments in rabbits. Eighteen healthy New Zealand White rabbits weighing 2.5-3.1 kg were transplanted with three different types of trachea substitutes. Two rabbits and two alpha 1, 3-galactosyltransferase gene-knockout pigs weighing 5 kg were used as donors. The rabbits were divided into three groups: an allograft control group consisting of rabbit-to-rabbit allotransplantation animals (n = 6), a fresh xenograft group consisting of pig-to-rabbit xenotransplantation animals (n = 6), and an artificial trachea scaffold group (n = 6). All animals were monitored for 4 weeks for anastomotic complications or infection. The recipients were sacrificed at 28 days after surgery and the grafts were evaluated. On bronchoscopy, all of the fresh xenograft group animals showed ischemic and necrotic changes at 28 days after trachea replacement. The allograft rabbits and the tissue-engineered rabbits showed mild mucosal granulation. The levels of interleukin-2 and interferon-γ in the fresh xenograft group were higher than in othe...Continue Reading

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Citations

Feb 24, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaT Yamaoka
Sep 17, 2019·Connective Tissue Research·Roberto Di GesùRiccardo Gottardi
Oct 14, 2020·Tissue Engineering. Part B, Reviews·Allison M Greaney, Laura E Niklason
Aug 10, 2021·The International Journal of Artificial Organs·Jaime Villalba-CalocaJ Alfredo Santibáñez-Salgado

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