Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials

Frontiers in Neuroscience
L DelheyRichard E Frye

Abstract

Autism spectrum disorder (ASD) affects about 1 in 45 individuals in the United States, yet effective treatments are yet to be defined. There is growing evidence that ASD is associated with abnormalities in several metabolic pathways, including the inter-connected folate, methylation and glutathione pathways. Several treatments that can therapeutically target these pathways have been tested in preliminary clinical trials. The combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) and sapropterin, a synthetic form of tetrahydrobiopterin (BH4) have been studied in open-label trials while high-dose folinic acid has been studied in a double-blind placebo controlled trial. All of these treatments have the potential to positively affect folate, methylation and glutathione pathways. Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways. Furthermore, the recent study using high-dose folinic acid (HDFA) did not analyze the change in metabolism resulting from the treatment. Thus, we compared changes ...Continue Reading

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Citations

Dec 6, 2019·Current Pharmaceutical Design·Iliyana Pacheva, Ivan Ivanov
Oct 2, 2019·Frontiers in Psychiatry·Terry HarvilleRichard E Frye
Jun 20, 2019·Behavioral Sciences·María Andrea CastilloDario Siniscalco
Nov 14, 2019·Translational Psychiatry·Nathaniel W HodgsonRichard C Deth
Jul 3, 2021·Journal of Personalized Medicine·María Luján Ferreira, Nicolás Loyacono
Sep 3, 2021·Oxidative Medicine and Cellular Longevity·Natália Cruz-MartinsWilliam C Cho

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