Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis

Clinical and Experimental Otorhinolaryngology
Bo Hae KimSoon-Hyun Ahn

Abstract

This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses. Twenty-five retrospective case-series studies were included in these analyses. Treatment strategies were classified as total laryngectomy (TL), open partial laryngectomy (PL), transoral laser microsurgery (TLM), chemo-radiation therapy (CRT), and radiation therapy (RT) alone. The overall survival rate and disease-specific survival rate among laryngeal preservation treatments did not differ from the overall survival rate of TL. However, the local control rate was lower with RT than TL and PL, and laryngeal preservation rates of TLM and CRT were higher than RT alone. Consideration of preservation of laryngeal function is necessary when treating T3 glottic squamous cell carcinoma. PL, TLM, and, CRT are considered more appropriate initial laryngeal preservation strategies if available.

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Citations

Dec 21, 2019·Journal of Cancer Research and Clinical Oncology·Won Ki ChoSang Yoon Kim
Oct 17, 2019·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Jakob PugiMichael Gupta
Feb 27, 2019·Journal of Cancer Research and Clinical Oncology·Won Ki ChoSang Yoon Kim
Jul 29, 2019·Journal of Cancer Research and Clinical Oncology·Yeonjoo ChoiSang Yoon Kim
Jul 6, 2020·Journal of Cancer Research and Clinical Oncology·Jaewang LeeJong-Lyel Roh
Jan 4, 2022·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marco de VincentiisRaul Pellini

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