Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil

Pediatric Blood & Cancer
Saunders C HsuScott C Howard

Abstract

Pediatric Hodgkin lymphoma (HL) has a cure rate of more than 80% in high-income countries (HIC). However, more than 80% of the world's children live in low-income countries (LIC), where the cure rate is often much lower. We compared the outcome of HL of 371 patients treated at two pediatric oncology centers in the US to that of 62 patients treated at one center in Recife, Brazil (IMIP) to determine whether the same treatment strategy should be used in both high-income and LIC. The logrank test was used to compare event-free and overall survival. The percentages of patients with unfavorable disease at each center were similar (P = 0.72). Patients with favorable disease at IMIP had estimated 5-year survival rates comparable to those of the US centers (100% and 99%, respectively). Among patients with unfavorable disease, those treated at IMIP had a 5-year event-free survival (EFS) rate of 60%, compared to 78% at the US centers; (P = 0.08). The 5-year survival estimate after relapse was 25% at IMIP versus 61% at the US centers (P = 0.08). The 5-year overall survival for patients with unfavorable disease was 72% at IMIP versus 90% at the US centers (P = 0.01). Intensive frontline therapy should be considered for patients with unfavo...Continue Reading

References

Sep 15, 1983·Cancer·N Gad-El-MawlaM N El-Bolkainy
Feb 1, 1996·Medical and Pediatric Oncology·S L FariaS R Brandalise
Mar 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BaezG Masera
Oct 26, 2001·Hematology/oncology Clinics of North America·J A Wilimas, R C Ribeiro
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah S DonaldsonHoward J Weinstein
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alison M FriedmannMichael P Link
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James B NachmanUNKNOWN Children's Cancer Group
Nov 12, 2002·Medical and Pediatric Oncology·T G SagarS G Raman
Nov 5, 2003·Medical and Pediatric Oncology·Peter B HesselingGlynn Wessels
May 27, 2004·JAMA : the Journal of the American Medical Association·Scott C HowardFrancisco Pedrosa
Nov 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melissa M HudsonHoward J Weinstein

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Citations

Aug 7, 2009·Journal of Tropical Pediatrics·Sebastian O EkenzeIfeoma J Emodi
Oct 18, 2012·Journal of Pediatric Hematology/oncology·Amita TrehanRadhika Srinivasan
Sep 9, 2008·Acta Oncologica·Münevver BüyükpamukçuTezer Kutluk
Dec 12, 2007·Cancer·Scott C HowardRaul C Ribeiro
Aug 14, 2012·International Journal of Cancer. Journal International Du Cancer·Roberto Rivera-LunaManuel Aguilar-Romo
Dec 19, 2013·Pediatric Blood & Cancer·E Mauricio CastellanosPedro A de Alarcón
Nov 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raul C RibeiroChing-Hon Pui
Mar 16, 2019·Science·Catherine G LamKathy Pritchard-Jones
Nov 3, 2017·Journal of Global Oncology·Venkatraman RadhakrishnanTenali Gnana Sagar
Oct 31, 2020·Cancer Epidemiology·Paula Carolina Guzman CEsther de Vries

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