Comparison of tri-exponential decay versus bi-exponential decay and full fitting versus segmented fitting for modeling liver intravoxel incoherent motion diffusion MRI

NMR in Biomedicine
Olivier ChevallierYi-Xiang Wang

Abstract

To determine whether bi- or tri-exponential models, and full or segmented fittings, better fit the intravoxel incoherent motion (IVIM) imaging signal of healthy livers. Diffusion-weighted images were acquired with a 3 T scanner using a respiratory-triggered echo-planar sequence and 16 b-values (0-800 s/mm2 ). Eighteen healthy volunteers had their livers scanned twice in the same session, and then once in another session. Liver parenchyma region-of-interest-based measurements were processed with bi-exponential and tri-exponential models, with both full fitting and segmented fitting (threshold b-value = 200 s/mm2 ). With the signal of all scans averaged, bi-exponential model full fitting showed Dslow  = 1.14 × 10-3  mm2 /s, Dfast  = 193.6 × 10-3  mm2 /s, and perfusion fraction (PF) = 16.9%, and segmented fitting showed Dslow  = 0.98 × 10-3  mm2 /s, Dfast  = 42.2 × 10-3  mm2 /s, and PF = 23.3%. IVIM parameters derived from the tri-exponential model were similar for full fitting and segmented fitting, with slow (D'slow  = 0.98 × 10-3  mm2 /s; F'slow  = 76.4 or 76.6%), fast (D'fast  = 15.1 or 15.4 × 10-3  mm2 /s; F'fast  = 11.8 or 11.7%) and very fast (D'Vfast  = 445.0 or 448.8 × 10-3  mm2 /s; F'Vfast  = 11.8 or 11.7%) diffusion com...Continue Reading

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Citations

Dec 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lauren A ScottLaura M Parkes
Jan 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julia StabinskaHans-Jörg Wittsack
Aug 29, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tobit FühresFrederik Bernd Laun

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