Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS

Neurology
Massimo FilippiG Comi

Abstract

We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity of brain MRI for detecting enhancing lesions in patients with MS. We obtained T1-weighted brain MRI scans in two sessions for 22 patients with clinically definite MS. In the first session, we obtained one scan 5 to 7 minutes after the injection of 0.1 mmol/kg gadolinium-DTPA (standard dose). In the second session, 6 to 24 hours later, we obtained one scan before the two scans 5 to 7 minutes (for all patients) and one hour (for 11 patients) after the injection of 0.3 mmol/kg gadolinium-DTPA (triple dose). We detected 83 enhancing lesions in 14 patients when the standard dose of gadolinium-DTPA was used. The numbers of enhancing lesions increased to 138 (average increase 66%; p = 0.001) and the numbers of patients with such lesions to 18 (increase 28%) when we used the triple dose of gadolinium-DTPA. In addition, the total area per patient occupied by such lesions was greater (p < 0.0001) and lesion signal intensity higher (p = 0.0001) on the triple-dose scans than the standard-dose scans. There was an increase in the number of large enhancing lesions (p = 0.03) in the scans obtained 1 hour after the injecti...Continue Reading

Citations

Dec 1, 1996·Italian Journal of Neurological Sciences·M FilippiG Comi
Jan 6, 2005·Neuroradiology·S J HickmanD H Miller
Jan 28, 2006·European Radiology·Francesco SardanelliMassimo Filippi
Apr 15, 2003·Current Neurology and Neuroscience Reports·Francesca Bagnato, Joseph A Frank
Jun 6, 2003·Clinical Radiology·P M Pretorius, G Quaghebeur
Sep 19, 1998·Journal of the Neurological Sciences·M FilippiG Comi
Dec 22, 1999·Journal of the Neurological Sciences·M Rovaris, M Filippi
Jul 20, 2002·Clinical Neurology and Neurosurgery·David H Miller
Nov 24, 1999·European Journal of Radiology·K TsuchiyaT Maehara
Dec 19, 2000·Magnetic Resonance Imaging·I YousryT A Yousry
Jan 24, 2006·Investigative Radiology·Kirsten NielsenOlaf B Paulson
Jul 21, 2009·Cephalalgia : an International Journal of Headache·M AshinaJ Olesen
Jun 1, 1997·Acta Neurologica Scandinavica·M FilippiG Comi
Oct 21, 2005·Neurosurgery·Robert J YoungEdmond A Knopp
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David H Miller
Apr 21, 2006·Expert Review of Neurotherapeutics·Francesca BagnatoVasiliki N Ikonomidou
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H VerheyBrenda Banwell
Jul 9, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·A RoviraJ M Prieto
Apr 27, 2010·Clinical Neurology and Neurosurgery·Mohammad Ali Sahraian, Arman Eshaghi
Jun 30, 2009·Revue neurologique·T TourdiasV Dousset
Dec 11, 2008·Neuroimaging Clinics of North America·Anthony Traboulsee, David K B Li
Dec 11, 2008·Neuroimaging Clinics of North America·Robert A BermelJeffrey A Cohen
Apr 3, 2007·Journal of the Neurological Sciences·Arnaud Charil, Massimo Filippi
Jul 20, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F BagnatoE Millefiorini
Jun 27, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S SchimrigkH Przuntek
Jul 26, 2005·European Journal of Radiology·Alessandro SteccoAlessandro Carriero
May 10, 2002·Neuroimaging Clinics of North America·Roland Bammer, Franz Fazekas
Jan 22, 2005·Neurologic Clinics·Anthony TraboulseeDavid K B Li
Apr 14, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Leo J WolanskyStuart D Cook
Apr 14, 2016·BMC Neurology·Steven M LeVine

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