Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?

The American Journal of Surgical Pathology
Sunhee S KimGrace E Kim

Abstract

To assess whether the College of American Pathologists (CAP) and the Evans grading systems for neoadjuvant chemotherapy without radiation-treated pancreatectomy specimens are prognostic, and if a 3-tier stratification scheme preserves data granularity. Conducted retrospective review of 32 patients with ordinary pancreatic ductal adenocarcinoma treated with neoadjuvant therapy without radiation followed by surgical resection. Final pathologic tumor category (AJCC eighth edition) was 46.9% ypT1, 34.4% ypT2, and 18.7% ypT3. Median follow-up time was 29.8 months, median disease-free survival (DFS) was 19.6 months, and median overall survival (OS) was 34.2 months. CAP score 1, 2, 3 were present in 5 (15.6%), 18 (56.3%), and 9 (28.1%) patients, respectively. Evans grade III, IIb, IIa, and I were present in 10 (31.2%), 8 (25.0%), 7 (21.9%), and 7 (21.9%) patients, respectively. OS (CAP: P=0.005; Evans: P=0.001) and DFS (CAP: P=0.003; Evans: P=0.04) were statistically significant for both CAP and Evans. Stratified CAP scores 1 and 2 versus CAP score 3 was statistically significant for both OS (P=0.002) and DFS (P=0.002). Stratified Evans grades I, IIa, and IIb versus Evans grade III was statistically significant for both OS (P=0.04) an...Continue Reading

References

Apr 14, 2005·Annals of Surgical Oncology·Rebekah R WhiteDouglas S Tyler
Jul 26, 2006·Annals of Surgical Oncology·Gauri R VaradhacharyRobert A Wolff
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William SmallCornelius J McGinn
Mar 1, 2008·American Journal of Surgery·Kimberly M BrownJohn P Hoffman
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gauri R VaradhacharyDouglas B Evans
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas B EvansRobert A Wolff
Apr 28, 2010·Annals of Surgical Oncology·Nabil WasifJames S Tomlinson
Feb 19, 2011·Journal of Hepato-biliary-pancreatic Sciences·Shinichiro TakahashiMasafumi Ikeda
Apr 27, 2011·Journal of Surgical Oncology·Manish PatelGregory Springett
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Jan 3, 2012·Archives of Pathology & Laboratory Medicine·Douglas J Hartman, Alyssa M Krasinskas
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Raphael L C AraujoPeter J Allen
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Jun 13, 2015·Annals of Surgical Oncology·Eran SadotPeter J Allen
Sep 30, 2016·Journal of Clinical Pathology·Sangeetha N KalimuthuRunjan Chetty
Aug 5, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Reetesh K Pai, Rish K Pai
Oct 12, 2017·World Journal of Surgical Oncology·Mashaal DhirChandrakanth Are
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 31, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Caroline VerbekeIrene Esposito

❮ Previous
Next ❯

Citations

May 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kohei FujikuraLaura D Wood
Mar 13, 2021·The British Journal of Surgery·S van RoesselM G Besselink

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
Pancreatectomy
MDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.