Comparison of two assays measuring human chorionic gonadotrophin serum concentrations in pregnancy termination and trophoblastic or non-trophoblastic tumours

Scandinavian Journal of Clinical and Laboratory Investigation
Fleur WolffFrédéric Cotton

Abstract

Differences in human chorionic gonadotrophin (hCG) results provided by the commercial immunoassays reflect the heterogeneity of antibodies and the use of suboptimal standards. As a consequence, the principal forms of hCG and metabolites are differentially detected and the hCG tests are not suited for the same clinical applications. Conflicting results are available in the literature regarding which hCG variants are recognized by the Roche Elecsys hCG + β test. The aim of our study was to compare the hCG concentrations provided by the Siemens Immulite 2000 test and the Roche test as well as to assess the concordance between both assays. In this purpose, 152 samples obtained from women and 44 samples from men were analysed by both tests during the follow-up of pregnancy termination, gestational trophoblastic disease and malignancies. The intermediate precision of the Roche test was also investigated on a pool with a low hCG concentration. The hCG concentrations measured with the Roche test were slightly lower compared with the Siemens assay; mean biases of -34.2% and -8% were respectively obtained for hCG values ≤100 UI/L and higher than 100 UI/L. The overall agreement between both assays was 96.1% for women and 97.7% for men. By...Continue Reading

References

Jan 1, 1992·Acta Oncologica·K D Bagshawe
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·U H StenmanJ O'Connor
Jul 6, 2004·Clinical Biochemistry·Ulf-Håkan StenmanKristina Hotakainen
Nov 23, 2006·Molecular and Cellular Endocrinology·C M Sturgeon, A R Ellis
Oct 22, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·JoDell WhittingtonDavid G Grenache
Aug 26, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laurence A ColeTrefor N Higgins
Dec 14, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Laurence A Cole
Mar 30, 2012·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Oct 4, 2012·Fertility and Sterility·Beata E Seeber
Sep 24, 2014·Trends in Endocrinology and Metabolism : TEM·Peter Berger, Catharine Sturgeon
Jun 24, 2015·Fertility and Sterility·Mahmood BakhtiyariFatemeh Sadat Sarfjoo
Nov 18, 2015·American Journal of Clinical Pathology·Dina N GreeneUNKNOWN Education Committee of the Academy of Clinical Laboratory Physicians and Scientist

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
K D BagshaweP H Sizaret
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Juliana Maria Quinalha de SouzaIzildinha Maestá
© 2022 Meta ULC. All rights reserved