Comparison of two consecutive fat-rich and carbohydrate-rich meals on postprandial myeloperoxidase response in women with and without type 2 diabetes mellitus

Metabolism: Clinical and Experimental
Roger K SchindhelmPeter G Scheffer

Abstract

Patients with type 2 diabetes mellitus (DM2) have an increased risk of cardiovascular disease (CVD). Myeloperoxidase (MPO), expressed in leukocytes and released upon activation, is associated with CVD and endothelial dysfunction. Postprandial leukocyte recruitment and activation with subsequent MPO release may contribute to atherosclerosis and CVD. We hypothesized that MPO may increase in the postprandial state because of postprandial leukocyte recruitment and/or activation, especially in subjects with DM2. One hundred postmenopausal women, aged 50 to 65 years (66 with normal glucose metabolism [NGM] and 34 with DM2), received 2 consecutive fat-rich meals and 2 consecutive carbohydrate-rich meals on separate occasions. Blood samples were taken before (t = 0) and at 2, 4, and 8 hours after breakfast; lunch was given at t = 4. Plasma MPO concentration was measured by sandwich enzyme-linked immunosorbent assay. The number of leukocytes in fasting blood samples was higher in DM2 compared with NGM (6.1 +/- 1.4 and 5.4 +/- 1.2 x 10(9)/L, respectively; P < .05). Baseline MPO concentration did not significantly differ between NGM and DM2 (51.4 +/- 12.9 and 54.5 +/- 18.4 mug/L, respectively; P = .39). Baseline MPO was positively associa...Continue Reading

References

Jun 6, 1974·The New England Journal of Medicine·G D FriedmanA B Siegelaub
Oct 10, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·W M Nauseef
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Nov 22, 2001·JAMA : the Journal of the American Medical Association·R ZhangS L Hazen
Feb 4, 2003·Journal of Lipid Research·A J H H M van OostromM Castro Cabezas
Sep 4, 2003·Circulation·Stephan BaldusUNKNOWN CAPTURE Investigators
Oct 19, 2004·Atherosclerosis·A J H H M van OostromM Castro Cabezas
Jan 11, 2005·Postgraduate Medical Journal·M E TushuizenR J Heine
Apr 27, 2005·Biochemical and Biophysical Research Communications·Alan P Kumar, Wanda F Reynolds
Sep 27, 2005·Trends in Cardiovascular Medicine·Stephen J NichollsStanley L Hazen
Feb 16, 2006·Pharmacology & Therapeutics·Denise Lau, Stephan Baldus
Feb 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tao ZhouHong-Nian Zhou
Jun 6, 2006·Journal of the American College of Cardiology·Markus ExnerMartin Schillinger
Jul 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pi-Yueh ChangJames T Wu
Sep 5, 2006·The American Journal of Cardiology·W H Wilson TangStanley L Hazen

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Citations

Feb 10, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F R JornayvazR W James
Apr 12, 2020·Scientific Reports·Mohammad G QaddoumiJehad Abubaker
Feb 19, 2013·Biomedit︠s︡inskai︠a︡ khimii︠a︡·I V GorudkoA M Panasenko

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