PMID: 8949696Sep 1, 1996Paper

Comparison of two cotside methods for the detection of hypoglycaemia among neonates in Nepal

Archives of Disease in Childhood. Fetal and Neonatal Edition
M EllisA M de L Costello

Abstract

To compare two cotside methods of blood glucose measurement (HemoCue and Reflolux II) against a standard laboratory method for the detection of neonatal hypoglycaemia in a developing country maternity hospital where hypoglycaemia is common. 94 newborn infants and 75 of their mothers had blood glucose assessed on the same venous sample using three different methods in the Special Care Baby Unit and postnatal wards, Prasuti Griha Maternity Hospital, Kathmandu, Nepal: HemoCue and Reflolux II at the cotside; Roche Ultimate glucose oxidase method (GOM) in the laboratory. The mean (SD) values for blood glucose in newborn infants were GOM 2.5 (1.1) mmol/l; Reflolux II 2.1 (0.9); and HemoCue 4.2 (1.2). For mothers the values were GOM 5.3 (1.2) mmol/l; Reflolux II 3.6 (1.2); and HemoCue 5.6 (1.0). Bland-Altman plots showed that Reflolux II consistently underreads GOM blood glucose in neonates by 0.5 mmol/l (SD 0.7) and that HemoCue overreads glucose by 1.7 mmol/l (SD 0.8). For the detection of hypoglycaemia (< 2.0 mmol/l), Reflolux II achieved a sensitivity of 83%, a specificity of 62%, and a likelihood ratio of 2.2. HemoCue produced a sensitivity of 0% and a specificity of 100% using measured values. If 2.0 mmol were subtracted from al...Continue Reading

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Citations

Aug 10, 2000·Indian Journal of Pediatrics·M A BhatA Narang
Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Nancy E Wight
Jun 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·H T HoB W Y Young
May 16, 2014·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Nancy WightUNKNOWN Academy of Breastfeeding Medicine
Nov 1, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Carlo BelliniEugenio Bonioli
Apr 20, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Pracha NuntnarumitSomying Goonthon
Aug 12, 2000·Journal of Paediatrics and Child Health·C L ThomasM W Davies
May 1, 1997·Annals of Clinical Biochemistry·M LeonardD Manning

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