Comparison of two different enzyme immunoassays for detection of immunoglobulin M antibodies against tick-borne encephalitis virus in serum and cerebrospinal fluid.

Journal of Clinical Microbiology
F X HeinzF Deinhardt

Abstract

Two enzyme immunoassays for the detection in immunoglobulin M (IgM) antibodies against tick-borne encephalitis virus were compared, employing a solid phase coated either with antigen or with mu-chain-specific antiserum to human IgM. The latter IgM-capturing assay system proved to be more sensitive, and its superiority was especially prominent when high titers of tick-borne encephalitis virus-specific IgG antibodies in addition to specific IgM antibodies were present in the sample. The application of this test is a valuable extension of the diagnostic tools for the rapid diagnosis of tick-borne encephalitis by IgM detection. Since specific IgG does not interfere, diagnosis can be readily established when patients have already developed high titers of IgG antibodies relatively late after the onset of the disease.

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Citations

Jan 1, 2011·Infection Ecology & Epidemiology·Göran GüntherBirgit Sköldenberg
Dec 8, 2005·CNS Drugs·Göran Günther, Mats Haglund
Jun 27, 2006·Scandinavian Journal of Infectious Diseases·Yves HansmannDaniel Christmann
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Jun 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C Granberg, O Meurman
Oct 29, 1997·Journal of Virology·C M O'NealM E Conner

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