Comparison of Two Different Intranasal Doses of Dexmedetomidine in Children for Magnetic Resonance Imaging Sedation

Paediatric Drugs
Aslihan TugSibel Oba

Abstract

Anaesthetic agents used for magnetic resonance imaging (MRI) in paediatric patients should cause few adverse effects and allow fast anaesthetic induction and recovery. The administration route is also important and should be minimally invasive. In this study, we aimed to compare two different doses of intranasal dexmedetomidine applied to children for MRI sedation. Sixty patients between 1 and 10 years of age with American Society of Anesthesiologists Physical Status classification I or II who were scheduled for MRI were recruited into this prospective, randomized, double-blind study. Intranasal dexmedetomidine was administered at doses of 3 µg kg(-1) (Group 1) and 4 µg kg(-1) (Group 2) before imaging. Heart rate (HR), peripheral oxygen saturation, respiratory rate and Ramsay Sedation Scale (RSS) scores were recorded before the anaesthetic induction of sedation and every 10 min until discharge. If intranasal sedation failed, an intravenous cannula was placed and propofol was applied as a rescue anaesthetic. Bispectral Index (BIS) scores were also recorded before and after MRI. We recorded onset time of sedation, mood at separation from parents (defined as parental separation score), imaging quality, MRI duration, rescue anaesth...Continue Reading

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Citations

May 1, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Desiree N W NevilleRaymond D Pitetti
Mar 28, 2017·British Journal of Clinical Pharmacology·Mary WeatherallSusana Perez-Gutthann
Jan 21, 2017·Clinical Pharmacokinetics·Maud A S WeerinkPieter Colin
Aug 26, 2018·Paediatric Anaesthesia·Jenny BuaLaura Travan
Apr 12, 2019·Hospital Pediatrics·Juan P BoriosiGregory A Hollman
Jun 28, 2019·Journal of Perioperative Practice·J Lewis, C R Bailey
Aug 18, 2017·Current Opinion in Anaesthesiology·Jasper DeenPeter Van de Putte
Jul 6, 2020·Journal of Gastrointestinal Cancer·Ahmed Abdel Ghafar SalehMohamed Abd El Ghaffar
Mar 25, 2017·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Natalie BehrleAbdallah Dalabih
Jan 25, 2018·Hospital Pediatrics·Gokhan Olgun, Mir Hyder Ali
Aug 5, 2017·Paediatric Anaesthesia·Giorgio CozziEgidio Barbi
Aug 28, 2020·Journal of Clinical Medicine·Mohamed MahmoudKeira P Mason
Jul 24, 2021·Cardiology in the Young·David E SaudekPeter C Frommelt
Jul 15, 2021·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Wei LiuWen Tang
Jun 27, 2021·Paediatric Anaesthesia·David Lozano-DíazAndrés Martínez Gutiérrez

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