Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trial

BMJ : British Medical Journal
Wolfram SterryBruce Freundlich

Abstract

To compare the efficacy over 12 weeks of two different etanercept regimens in treating the skin manifestations of psoriasis in patients who also have psoriatic arthritis and to evaluate efficacy and safety over an additional 12 weeks of open label etanercept treatment. Design Randomised double blind multicentre outpatient study. 98 outpatient facilities in Europe, Latin America, and the Asia Pacific region. Participants 752 patients with both psoriasis (evaluated by dermatologists) and psoriatic arthritis (evaluated by rheumatologists). During the blinded portion of the study, participants were randomised to receive etanercept 50 mg twice weekly (n=379) or 50 mg once weekly (n=373) for 12 weeks by subcutaneous injection. All participants then received open label etanercept 50 mg once weekly for 12 additional weeks, while remaining blinded to the regimen. The primary efficacy end point was the proportion of participants achieving "clear" or "almost clear" on the physician's global assessment of psoriasis at week 12. Secondary efficacy analyses included psoriasis area and severity index, American College of Rheumatology responses, psoriatic arthritis response criteria, and improvement in joint and tendon disease manifestations. A...Continue Reading

Citations

May 5, 2010·Current Rheumatology Reports·Aizad Mumtaz, Oliver FitzGerald
Apr 13, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Emily Yiping GanHong Liang Tey
Jan 30, 2014·Anais Brasileiros De Dermatologia·Emerson de Andrade LimaMaira Galdino da Rocha Pita
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Aman Sharma, Sunil Dogra
Sep 14, 2011·Nature Reviews. Rheumatology·Caroline A ChangPaul F Lizzul
Dec 14, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Lluís PuigCarmen García-Calvo
May 29, 2012·The Journal of Dermatological Treatment·Atsuyuki IgarashiBrad Schenkel
Feb 4, 2016·The Journal of Dermatological Treatment·Tian Hao ZhuTina Bhutani
Aug 5, 2014·Expert Review of Clinical Immunology·Minyoung Her, Arthur Kavanaugh
Nov 13, 2015·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Mar 25, 2014·Expert Opinion on Drug Safety·Giuseppe MurdacaFrancesco Puppo
Nov 14, 2013·Expert Opinion on Drug Safety·Carlo PalazziIgnazio Olivieri
May 8, 2010·Expert Opinion on Biological Therapy·Elizabeth E Uhlenhake, Steven R Feldman
Jan 15, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingUNKNOWN French Society for Rheumatology (SFR)
Apr 29, 2015·The British Journal of Dermatology·C E M GriffithsL Mallbris
Jul 29, 2011·Reumatología clinica·Jose Luis Fernández SueiroUNKNOWN Sociedad Española de Reumatología [Spanish Society of Rheumatology]
May 1, 2010·Seminars in Cutaneous Medicine and Surgery·F BachmannS Philipp
Jun 1, 2010·Annales de dermatologie et de vénéréologie·C Paul, M Solignac
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Philip J Mease
Sep 16, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·J C PrinzB Freundlich
Jan 10, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M-L SchaarschmidtW K Peitsch
Dec 8, 2011·Arthritis Care & Research·Penélope Esther PalominosLaure Gossec
Nov 1, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·R GniadeckiA S Zbrozek
Apr 18, 2013·Journal of Clinical Pharmacy and Therapeutics·S Fénix-CaballeroJ F López-Vallejo
Aug 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·W-H BoehnckeL Puig
Aug 5, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·C E M GriffithsL Mallbris
Feb 27, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·U MrowietzR B Warren
Nov 26, 2013·The British Journal of Dermatology·W H BoehnckeA B Gottlieb
Aug 6, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·W H BoehnckeP C M van de Kerkhof
May 28, 2014·The British Journal of Dermatology·C E M GriffithsL Mallbris
Apr 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·J C PrinzG Girolomoni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.