Comparison of two forms of daily preventive zinc supplementation versus therapeutic zinc supplementation for diarrhea on young children's physical growth and risk of infection: study design and rationale for a randomized controlled trial

BMC Nutrition
K Ryan WessellsSonja Y Hess

Abstract

Zinc is an essential nutrient that is required for children's normal growth and resistance to infections, including diarrhea and pneumonia, two major causes of child mortality. Daily or weekly preventive zinc supplementation has been shown to improve growth and reduce the risk of infection, while therapeutic zinc supplementation for 10-14 days is recommended for the treatment of diarrhea. The overall objective of the present study is to compare several regimens for delivering zinc to young children, both for the prevention of zinc deficiency and the treatment of diarrhea. The present study is a community-based, randomized controlled trial in the Lao People's Democratic Republic (PDR). Three thousand, four hundred children 6-23 months of age will be randomized to one of four intervention groups (daily preventive zinc dispersible tablet, daily preventive multiple micronutrient powder, therapeutic zinc dispersible tablet for diarrhea, or placebo control); interventions will be delivered for 9 months and outcomes measured at pre-determined intervals. Primary outcomes include physical growth (length and weight), diarrhea incidence, hemoglobin and micronutrient status, and innate and adaptive immune function. Secondary outcomes inclu...Continue Reading

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Citations

Feb 13, 2020·International Journal of Laboratory Hematology·Benchawan KingchaiyaphumSupan Fucharoen
Jul 7, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S GuptaN M Lowe
Apr 24, 2020·Heliyon·Harriet U UgbokoJohn O Oyewale

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Methods Mentioned

BETA
blood draw
blood collection
enzyme-linked immunosorbent assay
electrophoresis
light microscopy
PCR
ELISA

Clinical Trials Mentioned

NCT02428647

Software Mentioned

CommCare
- HQ
FACSCalibur

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