Comparison of two methods for selegiline determination: A flow-injection chemiluminescence method using cadmium sulfide quantum dots and corona discharge ion mobility spectrometry

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Alireza KhataeeSang Woo Joo

Abstract

Two analytical approaches including chemiluminescence (CL) and corona discharge ionization ion mobility spectrometry (CD-IMS) were developed for sensitive determination of selegiline (SG). We found that the CL intensity of the KMnO4-Na2S2O3 CL system was significantly enhanced in the presence of l-cysteine capped CdS quantum dots (QDs). A possible CL mechanism for this CL reaction is proposed. In the presence of SG, the enhanced CL system was inhibited. Based on this inhibition, a simple and sensitive flow-injection CL method was proposed for the determination of SG. Under optimum experimental conditions, the decreased CL intensity was proportional to SG concentration in the range of 0.01 to 30.0mgL(-1). The detection limit (3σ) was 0.004mgL(-1). Also, SG was determined using CD-IMS, and under optimum conditions of CD-IMS, calibration curves were linear in the range of 0.15 to 42.0mgL(-1), with a detection limit (3σ) of 0.03mgL(-1). The precision of the two methods was calculated by analyzing samples containing 5.0mgL(-1) of SG (n=11). The relative standard deviations (RSDs%) of the flow-injection CL and CD-IMS methods are 2.17% and 3.83%, respectively. The proposed CL system exhibits a higher sensitivity and precision than the...Continue Reading

References

Mar 6, 2003·Parkinsonism & Related Disorders·K F BhattacharyaH Kaufmann
Aug 9, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ayako KurikiKeizo Sato
Jun 7, 2011·Talanta·Paula R FortesElias A G Zagatto
Nov 6, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Mortaza Iranifam
Jan 1, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A R KhataeeS W Joo
Dec 3, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Bin DuHanchun Yao
May 20, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jianxiu DuWeimin Zhang
May 30, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Alireza KhataeeSang Woo Joo

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Citations

Mar 5, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alireza KhataeeMortaza Iranifam
Jun 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mortaza IranifamHaider A J Al Lawati

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