Comparison of two novel staging systems with the TNM system in predicting stage III colon cancer survival

Journal of Surgical Oncology
Richard WalkerFayez A Quereshy

Abstract

Adaptations of the TNM staging system that incorporate the Lymph Node Ratio (LNR) have been proposed for stage III colon cancer. This study compared the concordance of two novel staging systems and the TNM system with observed survival outcomes in stage III patients. A review of patients who underwent surgery for stage III colon cancer between January 2002 and April 2015 at a tertiary care centre was performed. The Kaplan-Meier method was used to estimate the 5-year overall (OS) and disease free survival (DFS) rates, and the concordance probability was calculated to evaluate the discriminatory power of the staging systems. Two hundred and sixty-one patients were identified. For TNM stages IIIA, IIIB, and IIIC, 5-year OS was 83.4%, 67.6%, and 38.3%, respectively (P < 0.001). All three staging systems were independently predictive of OS and DFS (P < 0.001). However, the novel staging system by Sugimoto et al18was the most favourable prognostic tool, with a concordance of 0.646 for DFS and 0.659 for OS. The novel staging system by Sugimoto et al18was superior to the TNM system. Incorporating LNR into staging models for node positive colon cancers may improve survival information available to patients and potentially aid treatment ...Continue Reading

References

Apr 20, 2001·Journal of the National Cancer Institute·H NelsonUNKNOWN National Cancer Institute Expert Panel
Oct 11, 2002·Annals of Surgical Oncology·Etsuro BandoKoichi Miwa
Jan 14, 2004·Diseases of the Colon and Rectum·Carlos A VaccaroJose M Lastiri
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Nancy N BaxterJoel E Tepper
Oct 5, 2006·Diseases of the Colon and Rectum·Paris P TekkisUNKNOWN Association of Coloproctology of Great Britain and Ireland
Jan 27, 2007·Annals of Surgical Oncology·Ho-Young LeeChoongrak Kim
Aug 19, 2007·American Journal of Surgery·Joshua M V MammenJeffrey J Sussman
Oct 6, 2007·Acta Oncologica·David EdlerPeter Ragnhammar
Mar 11, 2008·Annals of Surgical Oncology·Jiping WangMahmoud N Kulaylat
Mar 26, 2008·Annals of Surgery·Dean BogoevskiEmre F Yekebas
Sep 11, 2008·Journal of the National Cancer Institute·Karl Y BilimoriaClifford Y Ko
May 7, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hartwig RiedigerFrank Makowiec
Jul 3, 2009·Diseases of the Colon and Rectum·Carlos A VaccaroFernando A Bonadeo
Jul 8, 2010·Journal of Surgical Oncology·Kristoffer DerwingerTor Ekman
May 11, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iris D NagtegaalPhilip Quirke
Nov 22, 2011·Journal of the Korean Society of Coloproctology·Jin Yong Shin, Kwan Hee Hong
Jan 1, 2014·World Journal of Gastroenterology : WJG·Annika Resch, Cord Langner
Jul 25, 2014·International Surgery·Charles SabbaghUNKNOWN APCD-LNR-2011 study group
Feb 10, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J LykkeUNKNOWN Danish Colorectal Cancer Group

❮ Previous
Next ❯

Citations

Jan 9, 2019·Frontiers in Oncology·Chi-Hao ZhangMeng Luo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.