Comparison of two point-of-care lipid analyzers for use in global cardiovascular risk assessments

The Annals of Pharmacotherapy
Rita A DaleMori J Krantz

Abstract

Point-of-care (POC) lipid testing is increasingly used in community- and office-based practice. Two analyzers commonly used in the US are CardioChek PA and Cholestech LDX. Both directly measure total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), mandatory values in calculating a Framingham Risk Score (FRS). The FRS in turn informs the clinician of the need for lipid-modifying therapy and the degree of therapeutic intensity. To compare the performance of CardioChek PA and Cholestech LDX. Staff members from the Colorado Prevention Center were included in the study, with all having fasted for 12 hours before the testing. No medical history was obtained. A venous blood sample was collected for lipid measurements conducted in a laboratory, and 2 finger sticks were obtained at that time and analyzed immediately on-site using the POC analyzers. Intraclass correlation coefficients (ICCs) were determined for each analyzer versus the laboratory analysis, with values greater than 0.75 defined as indicators of excellent reproducibility. We then assessed how interanalyzer differences in TC or HDL-C impacted the FRS lipid categorization. Thirty-four adults (aged 24-56 y) participated in the study. The ICC between Cholest...Continue Reading

References

May 29, 1998·Circulation·P W WilsonW B Kannel
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Philip GreenlandPeter W Wilson
May 4, 2004·The Annals of Pharmacotherapy·Becky L Armor, Mark L Britton
Jun 5, 2004·The Annals of Pharmacotherapy·James R Taylor, Larry M Lopez
Jan 30, 2007·Australian Dental Journal·P A Leggat, D R Smith
Jun 8, 2007·The New England Journal of Medicine·Earl S FordSimon Capewell
Aug 2, 2007·Critical Pathways in Cardiology·Stephanie M Coronel, Mori J Krantz

❮ Previous
Next ❯

Citations

May 27, 2010·European Journal of Clinical Nutrition·C Mason, P T Katzmarzyk
Feb 2, 2010·American Journal of Veterinary Research·Elissa K KlugerMerran Govendir
Dec 17, 2011·Journal of American College Health : J of ACH·Jesse S MorrellRuth A Reilly
Aug 17, 2010·Contemporary Clinical Trials·David M JanickeJanet H Silverstein
Dec 15, 2015·Tropical Medicine & International Health : TM & IH·Paul H ParkSonak D Pastakia
Dec 3, 2010·Journal of Clinical Lipidology·Katherine R GerraldVirginia G Williams
Jun 23, 2009·The American Journal of Cardiology·Caitlin Mason, Peter T Katzmarzyk
Feb 17, 2009·Metabolism: Clinical and Experimental·Ruth M FranklinJill A Kanaley
Jun 28, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael J DuncanJose Carlos Ribeiro
Aug 26, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Daniel E BrownPeter T Katzmarzyk
Sep 25, 2014·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·Gia Mudd-MartinDebra K Moser
Feb 7, 2012·Metabolism: Clinical and Experimental·Caitlin A DowCynthia A Thomson
Dec 10, 2013·Journal of American College Health : J of ACH·Jesse Stabile MorrellGale B Carey
Apr 9, 2014·Journal of Clinical Pathology·Simon John WhiteheadRousseau Gama
Nov 20, 2013·The Diabetes Educator·Jie HuKaren A Amirehsani
Apr 29, 2016·Journal of Pharmacy Practice·Lauren Haggerty, Deanna Tran
Apr 2, 2016·Physiological Reports·Chandrakala Aluganti NarasimhuluSampath Parthasarathy
Jan 1, 2016·Analytical Methods : Advancing Methods and Applications·John A BowdenLouis J Guillette
Jun 18, 2016·Journal of Pharmacy Practice·Karen BastianelliJennifer Chen
Mar 21, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Annette PlüddemannCarl Heneghan
Oct 31, 2019·Ciência & saúde coletiva·Erika da Silva MacielFernando Adami
Aug 1, 2019·The Journal of Cardiovascular Nursing·Cilgy M AbrahamDebra K Moser
Nov 30, 2018·Journal of Clinical Medicine·Melissa D OlfertRachel A Wattick
May 27, 2020·Journal of Behavioral Medicine·Chantal A VellaMegan C Nelson
Mar 1, 2011·Annals of Clinical Biochemistry·Anjly JainDevaki R Nair
Jun 30, 2021·Journal of Occupational and Environmental Medicine·Shae C GurneyCharles L Dumke
Mar 21, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.