Comparison of type 1, type 2, and atypical ketosis-prone diabetes at 4 years of diabetes duration

Journal of Diabetes and Its Complications
María A Ramos-RománP Raskin

Abstract

Atypical ketosis-prone diabetes (KPD) is frequently detected in obese individuals at diagnosis of diabetes, yet its precise pathophysiology is not understood. The hypothesis tested in this study states that while individuals with atypical KPD are phenotypically similar to those with type 2 diabetes, metabolically, they behave more like individuals with autoimmune type 1 diabetes. Thirty-seven individuals of Black, Hispanic, or White background and a diagnosis of diabetes mellitus for an average duration of 4 years participated in this cross-sectional study. Ten, 12, and 15 subjects had type 1, atypical, and type 2 diabetes, respectively. Insulin secretion was evaluated by a mixed-meal test. Insulin sensitivity and fuel oxidation were assessed by simultaneous euglycemic hyperinsulinemic clamp and indirect calorimetry. Lastly, a 12-h insulin withdrawal test was performed. Insulin secretion, insulin sensitivity, and the insulin withdrawal tests yielded significant differences for type 1 vs. atypical diabetes and type 1 vs. type 2 diabetes, while there were no significant differences between atypical vs. type 2 diabetes. The indirect calorimetry showed higher-than-normal basal nonprotein respiratory quotients (RQs) and lower-than-n...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J E GerichD M Bier
Feb 5, 1987·The New England Journal of Medicine·W E WinterR P Spillar
Nov 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·P KoskinenP Seppälä
Jul 22, 1999·Diabetes Research and Clinical Practice·K TanakaY Yajima
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R H Unger, L Orci
May 26, 2001·Diabetes Care·A Piñero-PiloñaP Raskin
Oct 27, 2001·Diabetes Care·P H BennettJ Krakoff
Nov 17, 2001·Journal of Diabetes and Its Complications·A Piñero-Piloña, P Raskin
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Abbas E Kitabchi, Guillermo E Umpierrez
Mar 11, 2004·American Journal of Physiology. Endocrinology and Metabolism·Aidar R GosmanovDonald B Thomason
May 8, 2004·Metabolism: Clinical and Experimental·Petr WohlTerezie Pelikánová
Oct 29, 2004·Human Molecular Genetics·Franck Mauvais-JarvisChristian Vaisse
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Neda Rasouli, Steven C Elbein
Jan 22, 2005·Science·Stephen O'RahillyNicholas J Wareham

❮ Previous
Next ❯

Citations

Feb 23, 2008·Endocrine Reviews·Ashok BalasubramanyamMario Maldonado
Sep 24, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hui FanXinchun Yang
May 23, 2012·Diabetes Management·Dawn SmileyGuillermo E Umpierrez
Aug 19, 2007·Annales d'endocrinologie·L BelhadiA Farouqi
Jul 27, 2015·Journal of Diabetes and Its Complications·Aidar R Gosmanov, Niyaz R Gosmanov
May 28, 2013·International Journal of Endocrinology·Beiyan LiuLin Li
Mar 15, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Li ShiJin-Luo Cheng
May 24, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Priyathama Vellanki, Guillermo E Umpierrez
Oct 17, 2020·Annual Review of Medicine·Ashok Balasubramanyam
Jul 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Maria J Redondo, Ashok Balasubramanyam
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Jan 25, 2020·Clinical Diabetes : a Publication of the American Diabetes Association·Karen L ShidlerLucia M Novak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.