Comparison of urinary human follicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in polycystic ovarian syndrome

Fertility and Sterility
T LarsenC Felding

Abstract

A randomized, double-blind, crossover study was carried out to compare purified urinary follicle-stimulating hormone (FSH) and human menopausal gonadotropin (hMG) for ovarian stimulation in polycystic ovarian syndrome (PCOS). Twelve patients were stimulated with FSH and hMG in three alternate cycles. FSH, luteinizing hormone (LH), estradiol, dihydroepiandrosterone sulphate, free and total testosterone, delta 5-androstenedione, sex hormone binding globulin, and ovarian volume were monitored during the stimulation. There was no difference between the dose of FSH and hMG necessary to induce preovulatory follicles in the individual patients. The mean increase of ovarian volume during stimulation with FSH and hMG was 120% and 129% respectively (no significant difference). Two patients became pregnant in the first cycle. Two other patients had delayed bleeding and positive serum-human chorionic gonadotropin. No significant difference was found in the endocrine changes during the two different stimulation methods. The LH/FSH ratio was normalized after a few days of treatment regardless of the type of stimulation. The size of the material does not permit a comparison of the efficacy of the two treatment schedules. Our clinical and ultr...Continue Reading

Citations

Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Marco FilicoriSilvia Bernardi
Sep 28, 2005·Treatments in Endocrinology·Laurel Stadtmauer, Sergio Oehninger
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Jan 17, 2019·The Cochrane Database of Systematic Reviews·Nienke S WeissMadelon van Wely
Sep 10, 2015·The Cochrane Database of Systematic Reviews·Nienke S WeissMadelon van Wely
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Aug 25, 2015·The Cochrane Database of Systematic Reviews·David NugentRichard Lilford
Jun 23, 2005·Reproductive Biomedicine Online·Gamze Sinem CaglarSafaa Al-Hasani

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