Comparison of Urine 4-(Methylnitrosamino)-1-(3)Pyridyl-1-Butanol and Cotinine for Assessment of Active and Passive Smoke Exposure in Urban Adolescents

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Neal L BenowitzPeyton Jacob

Abstract

Background: Many adolescents are exposed to tobacco smoke, from either active smoking (CS) or secondhand smoke (SHS) exposure. Tobacco-specific biomarkers of exposure include cotinine (detects use in past 2-4 days) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL; detects use for a month or longer). NNAL is expected to detect more intermittent tobacco exposure. We compared NNAL and cotinine as biomarkers of exposure to tobacco in urban adolescents and determined the optimal NNAL cutoff point to distinguish CS from SHS exposure.Methods: Surplus urine samples, collected from 466 adolescents attending pediatric well or urgent care visits at Zuckerberg San Francisco General Hospital in 2013 to 2014, were assayed for cotinine and NNAL.Results: Ninety-four percent of adolescents had measurable levels of NNAL compared with 87% for cotinine. The optimal NNAL cutoff point to distinguish CS from SHS was 9.6 pg/mL by latent class or 14.4 pg/mL by receiver-operating characteristic analysis. Cotinine and NNAL were strongly correlated, but the correlation slopes differed for active versus SHS-exposed adolescents. Among nonsmokers, NNAL levels were significantly higher in African American (median, 3.3 pg/mL) compared with other groups ...Continue Reading

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Citations

Feb 15, 2019·Current Opinion in Pediatrics·Brian P Jenssen, Karen M Wilson
Sep 11, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Benjamin W ChaffeeNeal L Benowitz
Oct 2, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzMegan E Piper
Sep 9, 2018·Tobacco Control·Maciej Lukasz GoniewiczJonatan Tolentino
Aug 23, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Natalie NardoneNeal L Benowitz
Dec 7, 2018·International Journal of Environmental Research and Public Health·Sònia TorresNoelia Ramírez
Aug 28, 2020·Frontiers in Human Neuroscience·Shahnaza HamidullahJibran Y Khokhar
Sep 10, 2019·Expert Opinion on Drug Delivery·Natalie VoosThomas Eissenberg
Feb 26, 2020·Academic Pediatrics·Jessica GambinoKaren M Wilson
Dec 29, 2020·Addictive Behaviors Reports·Carol J BoydSean Esteban McCabe
Jan 21, 2021·International Journal of Environmental Research and Public Health·Rachel HeroldMaciej L Goniewicz
Feb 23, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gabriela R OatesWilliam T Harris
Mar 7, 2021·International Journal of Environmental Research and Public Health·Hernâni MarquesEugenia Gallardo
Mar 6, 2021·Preventive Medicine·Ashley L MerianosE Melinda Mahabee-Gittens
Mar 20, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniela S Gutiérrez-TorresNeal D Freedman
Sep 18, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jiyeon YangYoungwook Lim

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