PMID: 8446584Mar 1, 1993Paper

Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers

Proceedings of the National Academy of Sciences of the United States of America
G ScarlattiM Uhlén

Abstract

We have compared the variable region 3 sequences from 10 human immunodeficiency virus type 1 (HIV-1)-infected infants to virus sequences from the corresponding mothers. The sequences were derived from DNA of uncultured peripheral blood mononuclear cells (PBMC), DNA of cultured PBMC, and RNA from serum collected at or shortly after delivery. The infected infants, in contrast to the mothers, harbored homogeneous virus populations. Comparison of sequences from the children and clones derived from DNA of the corresponding mothers showed that the transmitted virus represented either a minor or a major virus population of the mother. In contrast to an earlier study, we found no evidence of selection of minor virus variants during transmission. Furthermore, the transmitted virus variant did not show any characteristic molecular features. In some cases the transmitted virus was more related to the virus RNA population of the mother and in other cases it was more related to the virus DNA population. This suggests that either cell-free or cell-associated virus may be transmitted. These data will help AIDS researchers to understand the mechanism of transmission and to plan strategies for prevention of transmission.

References

Sep 11, 1990·Nucleic Acids Research·T HultmanM Uhlén
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T J PalkerB F Haynes
Jun 22, 1989·The New England Journal of Medicine·R W RyderK Mwandagalirwa
Jan 1, 1988·Annual Review of Biochemistry·T W RademacherR A Dwek

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Citations

Jul 1, 1996·Journal of Biomedical Science·N. Ahmad
Oct 13, 2006·Acta Neuropathologica·Mingqi QuZhi-Ping Ren
Apr 10, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mauro PistelloMauro Bendinelli
Jul 1, 1996·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·P KasperK E Schneweis
Apr 14, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark A MicekLisa M Frenkel
Aug 4, 2001·AIDS Research and Human Retroviruses·V R YedavalliN Ahmad
Jun 29, 2001·AIDS Research and Human Retroviruses·M HusainN Ahmad
Jul 20, 2001·AIDS Research and Human Retroviruses·F Salvatori, G Scarlatti
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Apr 18, 2002·AIDS Research and Human Retroviruses·M A ArroyoL M Meléndez-Guerrero
Jul 17, 2001·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·P B GilbertM Essex
Mar 1, 1994·AIDS Research and Human Retroviruses·S OkaK Shimada
Mar 1, 1994·AIDS Research and Human Retroviruses·C L Kuiken, J Goudsmit
Oct 10, 1996·AIDS Research and Human Retroviruses·R D Fernández MedinaH Wigzell
Jul 1, 1996·AIDS Research and Human Retroviruses·W W RothV C Bond
Oct 28, 2006·AIDS Research and Human Retroviruses·M TagliamonteL Buonaguro
Nov 3, 2010·AIDS Research and Human Retroviruses·Athena P KourtisDenise J Jamieson
Jan 1, 1996·Epidemiologic Reviews·G C John, J Kreiss
Jun 1, 1996·Clinical Obstetrics and Gynecology·S L OrloffM E St Louis
Feb 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C DevitoH Wigzell
Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R SutthentC Wasi
Aug 26, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H J LinF B Hollinger
Apr 23, 2008·AIDS·Federico G HoffmannCharles Wood

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