Abstract
To determine the best lipid variable to predict coronary heart disease (CHD) in Japanese patients with type 2 diabetes. Eligible Japanese men and women (1,771) aged 40-70 years with type 2 diabetes from 59 institutes nationwide were followed for a planned 8-year period. The performance of eight conventional lipid variables, i.e., total cholesterol (TC), LDL-cholesterol (LDLC), HDL-cholesterol (HDLC), triglycerides (TGs), non-HDLC, TC/HDLC ratio, LDLC/HDLC ratio, and TG/HDLC ratio, as predictors of incident CHD were evaluated by four methods: hazard ratio (HR) per one SD increment by multivariate Cox analysis, χ(2) likelihood ratio test, area under the receiver operating characteristic curve (AUC), and tertile analysis. Although all variables significantly predicted CHD events in men, non-HDLC (HR per one SD 1.78 [95% CI 1.43-2.21]; AUC 0.726) and TC/HDLC (HR 1.63 [1.36-1.95]; AUC 0.718) had the better predictive performances among the variables, including LDLC. In women, TGs (log-transformed; HR 1.72 [1.21-2.43]; AUC 0.708) were the best predictor according to results of tertile analysis (HR of the top tertile versus the bottom tertile 4.31 [1.53-12.16]). The associations with incident CHD were linear and continuous. For Japane...Continue Reading
References
Oct 6, 2001·Diabetologia·E T LeeM Lu
Dec 28, 2002·Diabetes Care·Weiquan LuBarbara V Howard
Jan 9, 2003·Lancet·Hirohito SoneUNKNOWN Japan Diabetes Complication Study Group
Jun 24, 2003·Diabetologia·G BosUNKNOWN Hoorn Study
Jul 16, 2003·Acta Diabetologica·G T C KoC S Cockram
Jul 28, 2004·Diabetes Care·Rui JiangFrank B Hu
Sep 24, 2004·Diabetes/metabolism Research and Reviews·W B ChanJ C N Chan
Jan 22, 2005·Diabetologia·M B SchulzeF B Hu
Apr 21, 2005·Annals of Epidemiology·F BarziUNKNOWN Asia Pacific Cohort Studies Collaboration
Jun 29, 2005·Diabetes Care·Rury R HolmanRichard J Stevens
Jun 29, 2005·Diabetes Care·Ana María WägnerJordi Ordóñez-Llanos
Jul 21, 2005·JAMA : the Journal of the American Medical Association·Paul M RidkerJulie E Buring
Jul 27, 2005·Diabetes Care·Jian LiuScott M Grundy
Oct 11, 2005·International Journal of Cardiology·Chin-Hsiao TsengTong-Yuan Tai
Mar 10, 2006·Diabetologia·G BrunoP Cavallo-Perin
Mar 6, 2007·Diabetes Care·Kazumi SaitoNobuhiro Yamada
Jun 22, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Ian F GodslandNishi Chaturvedi
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Erik IngelssonRamachandran S Vasan
May 27, 2008·Lancet·Theodore MazzoneJorge Plutzky
Oct 17, 2008·Diabetes Research and Clinical Practice·L ZhangUNKNOWN DECODE Study Group
Oct 31, 2008·Diabetologia·V Charlton-MenysP N Durrington
Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Arshag D Mooradian
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Jul 9, 2009·Diabetes/metabolism Research and Reviews·L ZhangZ C Pang
Nov 13, 2009·Diabetes Care·Rafael BitzurDror Harats
Dec 31, 2009·PloS One·Kornelis J J van HaterenHenk J G Bilo
Jan 26, 2010·Lipids in Health and Disease·Maryam TohidiFereidoun Azizi
Jun 8, 2010·Diabetologia·M-R TaskinenUNKNOWN FIELD study investigators
Dec 3, 2010·Journal of Clinical Lipidology·Allan D SnidermanCurt D Furberg
Dec 3, 2010·Journal of Clinical Lipidology·Allan SnidermanCurt D Furberg
Feb 2, 2011·Nature Reviews. Cardiology·Benoit J ArsenaultJohn J P Kastelein
Apr 14, 2011·Circulation. Cardiovascular Quality and Outcomes·Allan D SnidermanCurt D Furberg
Apr 20, 2011·Circulation·Michael MillerUNKNOWN Council on the Kidney in Cardiovascular Disease
Apr 30, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ira J GoldbergRuth McPherson
Jul 22, 2011·Diabetes Care·Björn EliassonUNKNOWN National Diabetes Register
Jul 23, 2011·Journal of the American College of Cardiology·Vimal RamjeeTerry A Jacobson
Jul 26, 2011·Journal of Clinical Lipidology·John H ContoisAllan D Sniderman
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Hirohito SoneUNKNOWN Japan Diabetes Complications Study Group
Citations
Feb 28, 2013·Diabetologia·H SoneUNKNOWN Japan Diabetes Complications Study Group
Aug 13, 2013·Diabetes Research and Clinical Practice·Yujie WangGang Hu
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ali MovahedThomas Netticadan
Apr 17, 2013·Herz·Z YunkeC Zhenyue
Apr 29, 2014·Lipids in Health and Disease·Xiao-Lin LiJian-Jun Li
Apr 8, 2014·Journal of Diabetes and Its Complications·Toshiko TakaoShoji Kawazu
Jan 10, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hirohito SoneNobuhiro Yamada
Dec 3, 2015·BMJ Open Diabetes Research & Care·Toshiko TakaoYasuhiko Iwamoto
Dec 18, 2013·Journal of Diabetes and Its Complications·Toshiko TakaoShoji Kawazu
Nov 24, 2012·Ophthalmology·Ryo KawasakiUNKNOWN Japan Diabetes Complications Study Group
Mar 11, 2015·Journal of Atherosclerosis and Thrombosis·Takahisa HiroseUNKNOWN J-BENEFIT study group
May 21, 2013·International Journal of Epidemiology·Shiro TanakaUNKNOWN Japan Diabetes Complications Study Group
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Apr 5, 2016·Journal of Diabetes Investigation·Ronald C W Ma
Apr 10, 2015·Journal of Cellular Biochemistry·Li-Li GaoJun Cheng
Apr 12, 2015·Journal of Diabetes and Its Complications·Toshiko TakaoYutaka Matsuyama
Jul 6, 2014·Journal of Diabetes and Its Complications·Toshiko TakaoShoji Kawazu
Jan 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mayumi IdeiTakashi Miida
Sep 2, 2014·Nutrition Research·Shurong LyuMing Wu
Nov 2, 2014·Bioinformatics·Ryan TaylorJohn T Prince
Jun 10, 2017·Clinical Pharmacology in Drug Development·Yoshinori NodaToshitaka Yajima
Dec 16, 2016·Journal of Diabetes Investigation·Toshiko TakaoYasuhiko Iwamoto
Mar 7, 2018·PloS One·Carla I MercadoFleetwood Loustalot
Jul 26, 2019·The Proceedings of the Nutrition Society·Alan Fappi, Bettina Mittendorfer
Dec 8, 2019·Journal of Diabetes Investigation·Toshiko TakaoMasato Kasuga
Feb 29, 2020·Journal of Family Medicine and Primary Care·Montosh ChakrabortyPandurang V Thatkar
Aug 27, 2018·Lipids in Health and Disease·Chen ChiYa-Wei Xu
Apr 24, 2018·Annals of Vascular Diseases·Kazuya Fujihara, Hirohito Sone
Nov 30, 2018·Journal of Atherosclerosis and Thrombosis·Hirokatsu NiwaHideaki Miyoshi
Jan 30, 2021·Scientific Reports·Amna TahirSafee Ullah Chaudhary