Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study.

Diabetes Care
Hirohito SoneJapan Diabetes Complications Study Group

Abstract

To determine the best lipid variable to predict coronary heart disease (CHD) in Japanese patients with type 2 diabetes. Eligible Japanese men and women (1,771) aged 40-70 years with type 2 diabetes from 59 institutes nationwide were followed for a planned 8-year period. The performance of eight conventional lipid variables, i.e., total cholesterol (TC), LDL-cholesterol (LDLC), HDL-cholesterol (HDLC), triglycerides (TGs), non-HDLC, TC/HDLC ratio, LDLC/HDLC ratio, and TG/HDLC ratio, as predictors of incident CHD were evaluated by four methods: hazard ratio (HR) per one SD increment by multivariate Cox analysis, χ(2) likelihood ratio test, area under the receiver operating characteristic curve (AUC), and tertile analysis. Although all variables significantly predicted CHD events in men, non-HDLC (HR per one SD 1.78 [95% CI 1.43-2.21]; AUC 0.726) and TC/HDLC (HR 1.63 [1.36-1.95]; AUC 0.718) had the better predictive performances among the variables, including LDLC. In women, TGs (log-transformed; HR 1.72 [1.21-2.43]; AUC 0.708) were the best predictor according to results of tertile analysis (HR of the top tertile versus the bottom tertile 4.31 [1.53-12.16]). The associations with incident CHD were linear and continuous. For Japane...Continue Reading

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Citations

Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ali MovahedThomas Netticadan
Apr 8, 2014·Journal of Diabetes and Its Complications·Toshiko TakaoShoji Kawazu
Jan 10, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hirohito SoneNobuhiro Yamada
Nov 24, 2012·Ophthalmology·Ryo KawasakiUNKNOWN Japan Diabetes Complications Study Group
Mar 11, 2015·Journal of Atherosclerosis and Thrombosis·Takahisa HiroseUNKNOWN J-BENEFIT study group
May 21, 2013·International Journal of Epidemiology·Shiro TanakaUNKNOWN Japan Diabetes Complications Study Group
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Apr 5, 2016·Journal of Diabetes Investigation·Ronald C W Ma
Apr 10, 2015·Journal of Cellular Biochemistry·Li-Li GaoJun Cheng
Jan 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mayumi IdeiTakashi Miida
Nov 2, 2014·Bioinformatics·Ryan TaylorJohn T Prince
Jul 26, 2019·The Proceedings of the Nutrition Society·Alan Fappi, Bettina Mittendorfer
Feb 29, 2020·Journal of Family Medicine and Primary Care·Montosh ChakrabortyPandurang V Thatkar
Apr 24, 2018·Annals of Vascular Diseases·Kazuya Fujihara, Hirohito Sone

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Methods Mentioned

BETA
electrophoresis
coronary artery bypass

Software Mentioned

SAS

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