Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction.

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Munir BoodhwaniFrank W Sellke

Abstract

Growth factor based angiogenesis, with or without cell therapy, is a promising therapeutic modality for patients with coronary artery disease. We compared the relative efficacies of surgically delivered vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) in a swine model of hypercholesterolemia-induced endothelial dysfunction which captures many of the pathophysiologic abnormalities of human coronary disease. Yucatan mini-swine (20-30 kg), fed a high cholesterol diet (total 20 weeks), underwent circumflex ameroid placement to create chronic myocardial ischemia, followed three weeks later by perivascular administration of VEGF (2 microg; n=6), FGF-2 (100 microg; n=6), or placebo (n=7) in the ischemic territory. Normocholesterolemic animals (n=7) served as controls. Four weeks later, endothelial function, collateral-dependent perfusion, as well as myocardial protein and mRNA levels of angiogenic mediators were assessed. Endothelial dysfunction was observed in all hypercholesterolemic animals as impaired microvessel relaxation in response to adenosine diphosphate and VEGF. VEGF administration improved baseline-adjusted collateral-dependent perfusion at rest (-0.03+/-0.05 vs -0.12+/-0.04, VEGF vs placeb...Continue Reading

References

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Sep 19, 2006·Shock·Munir BoodhwaniFrank W Sellke

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Citations

Jun 30, 2011·Basic Research in Cardiology·Antonio D LassalettaFrank W Sellke
Feb 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gabor M Rubanyi
Feb 4, 2009·Antioxidants & Redox Signaling·Munir Boodhwani, Frank W Sellke
Jan 15, 2011·Journal of Cardiovascular Pharmacology·Michael P RobichFrank W Sellke
Nov 1, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Louis M ChuFrank W Sellke
Aug 8, 2012·Journal of the American College of Surgeons·Michael P RobichFrank W Sellke
Sep 10, 2010·Journal of Molecular and Cellular Cardiology·Michael P RobichFrank W Sellke
Aug 24, 2010·Journal of the American College of Surgeons·Michael P RobichFrank W Sellke
Dec 25, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Antonio D LassalettaFrank W Sellke
Dec 6, 2017·Molecular Medicine Reports·Lin LingLiucheng Ding
Mar 10, 2017·Expert Opinion on Biological Therapy·Kay MaedaMarc Ruel
Nov 9, 2011·Expert Review of Cardiovascular Therapy·Michael P RobichFrank W Sellke

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