Comparison of visceral fat measurement by dual-energy X-ray absorptiometry to computed tomography in HIV and non-HIV

Nutrition & Diabetes
Lindsay T FourmanSteven K Grinspoon

Abstract

Individuals with HIV are susceptible to visceral fat accumulation, which confers an increased risk of cardiometabolic disease. Advanced software to ascertain visceral fat content from dual-energy X-ray absorptiometry (DXA) has not been validated among this population. We sought to compare DXA with computed tomography (CT) in the measurement of visceral fat cross-sectional area (VAT) in HIV and non-HIV using Bland-Altman analyses. Data were combined from five previously conducted studies of individuals with HIV (n = 313) and controls without HIV (n = 144) in which paired DXA and CT scans were available. In cross-sectional analyses, DXA-VAT was compared with CT-VAT among participants with and without HIV. In longitudinal analyses, changes in VAT over time were compared between DXA and CT among participants with and without HIV receiving no intervention over 12 months and among individuals with HIV receiving tesamorelin-a medication known to reduce VAT-over 6 months. In HIV, DXA underestimated VAT compared with CT among individuals with increased visceral adiposity. The measurement bias was -9 ± 47 cm2 overall, but became progressively larger with greater VAT (P < 0.0001), e.g., -61 ± 58 cm2 among those with VAT ≥ 200 cm2. Sex-str...Continue Reading

References

Jun 1, 1990·The American Journal of Clinical Nutrition·R B MazessJ Hanson
May 1, 1993·The American Journal of Clinical Nutrition·O L SvendsenC Christiansen
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen HadiganSteven Grinspoon
Sep 17, 2003·Circulation·Tomoshige HayashiWilfred Y Fujimoto
Apr 13, 2004·Journal of Applied Physiology·Scott G GlickmanDonald R Dengel
Aug 28, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Colleen HadiganDushyant V Sahani
Nov 1, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tisha JoySteven K Grinspoon
Dec 7, 2007·The New England Journal of Medicine·Julian FalutzSteven Grinspoon
Jan 3, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carl GrunfeldSteven B Heymsfield
Jun 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Esteban Martínez
Jul 20, 2011·AIDS Care·Jordan E LakeJudith S Currier
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinFahim Abbasi
Jan 28, 2012·Obesity·Sanjiv KaulDavid L Ergun
Apr 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takara L StanleySteven K Grinspoon
Aug 10, 2012·AIDS·Kathleen V FitchSteven K Grinspoon
Jul 20, 2014·JAMA : the Journal of the American Medical Association·Takara L StanleySteven K Grinspoon
May 6, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Yong Jun ChoiYoon-Sok Chung
Jan 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace A McComseyTodd T Brown
Feb 3, 2016·Current HIV/AIDS Reports·Kristine M Erlandson, Jordan E Lake
Mar 24, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A S CheungM Grossmann
Dec 31, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Inês GrenhaPaula Freitas
Sep 16, 2017·Comprehensive Physiology·John R Koethe
Dec 7, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marshall J GlesbyAnjali Sharma

❮ Previous
Next ❯

Citations

Sep 30, 2020·Seminars in Musculoskeletal Radiology·Robert HemkeMartin Torriani
Feb 20, 2020·Current HIV/AIDS Reports·Samuel S BailinJohn R Koethe
Feb 11, 2020·Arthritis & Rheumatology·Shanshan LiUNKNOWN Multicenter Osteoarthritis Study Group
Apr 24, 2020·European Journal of Clinical Nutrition·Florence E DavidsonJulia H Goedecke
Dec 2, 2020·Metabolism: Clinical and Experimental·Qiang ZengUNKNOWN China Health Big Data (China Biobank) project investigators
Aug 19, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Jennifer W BeaAndrew O Odegaard

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Hologic Horizon A , APEX
JMP Pro
APEX
Horizon
ViTrak

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.