Comparison of Visual Acuity Outcomes Between Nanothin Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty

Cornea
Khaliq H KurjiEdward J Holland

Abstract

To compare the visual outcomes and complications between nanothin Descemet stripping automated endothelial keratoplasty (NT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). A prospective comparative case series of 28 consecutive cases of NT-DSAEK (less than or equal to 50 μm) and DMEK was undertaken. Inclusion criteria were a diagnosis of Fuchs dystrophy, presence of pseudophakia, or planned combined cataract surgery/endothelial keratoplasty, with a minimum of 6-month follow-up. Exclusion criteria were any concurrent ocular comorbidities. Primary outcomes measures were best spectacle-corrected visual acuity (BSCVA) and complications. Mean thickness of NT-DSAEK grafts was 41.0 ± 7.5 μm (range 26-50 μm). At 1 month postoperatively, the DMEK group had significantly better mean BSCVA of 0.18 ± 0.20 logarithm of the minimum angle of resolution (logMAR) (20/33) compared with 0.28 ± 0.16 logMAR (20/40) for NT-NSAEK (P = 0.049). At 3, 6, and 12 months postoperatively, mean BSCVA was comparable between both groups [3 months: NT-DSAEK 0.17 ± 0.12 logMAR (20/30) versus DMEK 0.13 ± 0.17 (20/27), P = 0.31; 6 months: NT-DSAEK 0.11 ± 0.10 logMAR (20/26) versus DMEK 0.09 ± 0.10 (20/25), P = 0.63; 12 months: NT-DSAEK 0.07 ± 0.09 lo...Continue Reading

References

Nov 15, 2006·Cornea·Gerrit R J MellesJacqueline van der Wees
Dec 27, 2011·Ophthalmology·Michael RudolphFriedrich E Kruse
Dec 30, 2011·Investigative Ophthalmology & Visual Science·Massimo BusinDiego Ponzin
Mar 9, 2012·American Journal of Ophthalmology·Theofilos TourtasFriedrich E Kruse
May 29, 2014·Current Opinion in Ophthalmology·Massimo Busin, Elena Albé
Dec 3, 2014·Ophthalmology·Marina Rodríguez-Calvo-de-MoraGerrit R J Melles
Aug 28, 2015·Cornea·Harry W RobertsMadhavan S Rajan
Sep 21, 2015·Ophthalmology·Choul Yong ParkRoy S Chuck
Mar 21, 2017·Journal of Cataract and Refractive Surgery·Vito RomanoStephen B Kaye

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Citations

Apr 30, 2019·Current Opinion in Ophthalmology·Asad F DurraniVishal Jhanji
Nov 27, 2019·Current Opinion in Ophthalmology·Caterina SarnicolaVincenzo Sarnicola
Jul 1, 2020·Advanced Healthcare Materials·Jasper Van HoorickBert Van den Bogerd
Jul 23, 2020·European Journal of Ophthalmology·Pedro BertinoLuciene Barbosa de Sousa
Aug 26, 2020·Ophthalmology and Therapy·Andrea L Blitzer, Kathryn A Colby
May 3, 2019·JAMA Ophthalmology·Alan Sugar
May 22, 2020·Progress in Retinal and Eye Research·Stephan Ong ToneUla V Jurkunas
Oct 3, 2018·Cornea·Albert Y CheungEdward J Holland
Mar 26, 2021·International Ophthalmology·Jorge Peraza-NievesJosep Torras-Sanvicens
Jun 23, 2021·American Journal of Ophthalmology·Robert W WeisenthalDavid D Verdier
Mar 27, 2021·Journal of Cataract and Refractive Surgery·Elizabeth YeuUNKNOWN ASCRS Cornea Clinical Committee

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