Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression

Translational Vision Science & Technology
Zhichao Wu, Felipe A Medeiros

Abstract

To compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma. The study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 years to develop a computer simulation model of "real-world" visual field results. Progression was evaluated with point-wise event-based analysis using the Guided Progression Analysis (GPA) and global trend-based analysis using the mean deviation (MD) and visual field index (VFI) measures. The specificities of the methods were matched based on a simulated dataset of stable glaucoma eyes, to allow an adequate comparison of their sensitivities for detecting progression. The 5-year cumulative false-positive rate for the GPA alert of "possible progression" and "likely progression" (significant change from baseline at two and three consecutive visits, respectively) were 34.0% and 7.0%, respectively. At matched specificities, 27.7% eyes were detected as having progressed after 5 years using the GPA "likely progression" criterion, while 24.6% and 23.8% were detected as having progressed using the global trend-based analysis with MD and VFI, respectively. There was a moderate level of agreement betwee...Continue Reading

References

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Oct 17, 2017·Ophthalmology·Ricardo Y AbeFelipe A Medeiros
Jun 28, 2018·Translational Vision Science & Technology·Zhichao Wu, Felipe A Medeiros

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Citations

Apr 3, 2020·JAMA Ophthalmology·Diana SalazarJoseph Caprioli
Dec 14, 2018·Pharmaceutical Research·Christopher M AdamsGanesh Prasanna
Oct 7, 2020·Progress in Retinal and Eye Research·Maximilian PfauSteffen Schmitz-Valckenberg
Apr 28, 2021·American Journal of Ophthalmology·Giovanni MontesanoDavid P Crabb
May 15, 2021·The British Journal of Ophthalmology·Brian StaggFelipe A Medeiros
Aug 13, 2021·Scientific Reports·Chiara RuiFrancesco Oddone

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Software Mentioned

Stata
GPA

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