PMID: 8592191Nov 1, 1995Paper

Comparison of voltage-dependent potassium currents in rat pyramidal neurons acutely isolated from hippocampal regions CA1 and CA3

Journal of Neurophysiology
R KleeU Heinemann

Abstract

1. The properties of voltage-gated potassium currents were studied in acutely isolated rat hippocampal pyramidal cells from area CA1 and CA3 at postnatal ages of day 6-8, 9-14, and 26-29 (P6-8, P9-14, and P26-29) with the use of the whole cell version of the patch-clamp technique. 2. The outward current pattern of all cells under investigation could be separated in a fast transient A current (IA) and a delayed rectifier-like current (IK). 3. In both preparations, IA activated and inactivated rapidly. Vh describing steady-state inactivation was -84.5 mV in CA3 cells and -85.5 mV in CA1 cells. The activation behavior was characterized by Vh = -23.8 mV in CA3 cells and -27.2 mV in CA1 cells. The removal of inactivation was monoexponential both in CA1 and CA3 neurons with time constants of 32.1 and 28.5 ms, respectively. IA was insensitive to tetraethylammonium (TEA), dendrotoxin (300 nM), and mast cell degranulating peptide (200 nM), but could be blocked with 5 mM 4-aminopyridine (4-AP) by approximately 80%. In both preparations, A currents did not depend on Ca2+ influx. 4. Delayed rectifier currents (IK) in CA1 and CA3 pyramidal neurons decayed along a double exponential time course. Steady-state inactivation was described by Vh ...Continue Reading

Citations

Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·N N Urban, G Barrionuevo
Feb 10, 2006·Journal of Neurophysiology·Carl GoldGyörgy Buzsáki
Apr 23, 2008·Molecular Membrane Biology·Jianli GuoZhi Qi
May 21, 2009·Epilepsia·L Forbes S BarnwellAnne E Anderson
Dec 31, 1997·The European Journal of Neuroscience·R KleeU Heinemann
Sep 23, 2014·The Journal of Physiology·Jörg Pohle, Josef Bischofberger
Apr 17, 2008·Journal of Molecular Neuroscience : MN·Tingsong LiXiaoping Zhang
Apr 24, 2014·The Journal of Physiology·A Sánchez-AguileraA Colino
Feb 19, 2016·Scientific Reports·Qi YuanGuangju Ji
Aug 17, 1999·Nature Neuroscience·N S DesaiG G Turrigiano
May 31, 2002·Journal of Neurophysiology·Wolfgang Müller, Katrin Bittner
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May 17, 2002·The Journal of Physiology·Ruth Ruscheweyh, Jürgen Sandkühler
Mar 22, 2008·Neurochemical Research·Manuel CovarrubiasGuangyu Wang
Oct 11, 2008·The Journal of Physiology·Jonathon Maffie, Bernardo Rudy
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Feb 13, 2001·Journal of Neuroscience Research·W B AlshuaibM A Fahim
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