PMID: 702052Sep 1, 1978Paper

Comparison of wild-type and subacute sclerosing panencephalitis strains of measles virus. Neurovirulence in ferrets and biological properties in cell cultures

The Journal of Experimental Medicine
H ThormarH R Brown

Abstract

The neurovirulence of two wild type (wt) and seven Subacute Sclerosing Panencephalitis (SSPE) measles virus strains was tested in young adult ferrets by intracerebral (IC) inoculation of infected Vero cell suspensions. Wt strains Edmonston and Woodfolk and SSPE strains Mantooth, Halle, and LEC-S did not produce a detectable encephalitis in the ferrets, but caused a significant formation of serum antibodies against measles virus. SSPE strains LEC, IP-3, Biken, and D.R., on the other hand, were all neurovirulent in ferrets, particularly strain D.R. which caused an acute encephalitis in all inoculated animals. Strain Biken was of particular interest since it caused a subacute encephalitis in four of seven ferrets. The subacute encephalitis was characterized by a long incubation time, persistence of virus in the brain for at least 8 mo, widespread inflammatory lesions, and production of measles virus specific IgG in the brain. A study of the biological properties of the various measles virus strains showed that wt strains Edmonston and Woodfolk and SSPE strains Mantooth, Halle, and LEC-S produced free virus particles in significant titers both in Vero and ferret brain (FB) cultures. Cytopathic effect (CPE) with cell-fusion was mark...Continue Reading

References

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Citations

Jan 1, 1981·Journal of Immunological Methods·D KarcherM Noppe
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C A Miller, D R Carrigan
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·J Schneider-SchauliesV ter Meulen
Apr 23, 2002·Journal of Virology·Richard K PlemperRoberto Cattaneo
Apr 1, 1984·Australian and New Zealand Journal of Medicine·S J RobbinsC Burke
Oct 12, 2016·Viruses·Renata da Fontoura Budaszewski, Veronika von Messling
Jul 19, 2018·MBio·Randy A AlbrechtStacey Schultz-Cherry

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