Comparison of wire and disc leads to activate the expiratory muscles in dogs.

The Journal of Spinal Cord Medicine
Krysztof E Kowalski, Anthony F DiMarco

Abstract

Respiratory complications account for a major cause of morbidity and mortality in subjects with spinal cord injury (SCI) due to paralysis of the expiratory muscles and the consequent inability to generate effective cough. We demonstrated previously that effective cough can be restored in SCI via spinal cord stimulation (SCS) with disc leads positioned on the lower thoracic and upper lumbar spinal cord via laminotomy incisions. In this study, the effectiveness of wire leads, which can be placed using minimally invasive techniques, to activate the expiratory muscles was evaluated. Animal study. Research laboratory. Dogs (n = 8). In separate trials, disc and wire leads were inserted onto the dorsal epidural space at the T9, T11, and L1 spinal cord levels. Effects of electrical stimulation with disc, single wire, and two wire leads placed in parallel were compared. Airway pressure generation following stimulation with disc and various configurations of wire leads were compared. Several different configurations of wire leads resulted in airway pressures that were similar to those generated with monopolar stimulation with disc leads (MSDLs). For example, combined monopolar stimulation with parallel wire leads at the T9 + T11 and...Continue Reading

Associated Clinical Trials

Aug 8, 2012·Anthony F. Dimarco

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Citations

Oct 5, 2013·The Journal of Spinal Cord Medicine·Anthony F DiMarcoRobert T Geertman
May 12, 2016·Journal of Neuroscience Methods·Krzysztof E KowalskiAnthony F DiMarco
Oct 12, 2017·The Journal of Spinal Cord Medicine·Anthony F DiMarcoKrzysztof E Kowalski
Jul 20, 2018·Journal of Applied Physiology·Euan J McCaugheyJane E Butler
Jan 18, 2018·Topics in Spinal Cord Injury Rehabilitation·Anthony F DiMarcoKrzysztof E Kowalski
Dec 15, 2018·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Felipe Soares MacedoSergio Ricardo Menezes Mateus
Aug 18, 2018·American Journal of Physical Medicine & Rehabilitation·Anthony F DiMarcoKrzysztof E Kowalski
Apr 6, 2021·Journal of Neuroscience Methods·Krzysztof E Kowalski, Anthony F DiMarco
Jul 8, 2021·The Journal of Spinal Cord Medicine·Anthony F DiMarcoKrzysztof E Kowalski

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