Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study

The American Journal of Emergency Medicine
Mohammadreza Maleki VerkiAdel Aryan

Abstract

Ureter muscles contraction movements caused pain in renal colic. Magnesium sulphate could influence the pain by reducing acetylcholine in the nerve terminals. We have aimed to evaluate the analgesic effects of magnesium sulphate on acute renal colic pain. In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac. The pain severity of patients was assessed using the visual analog scale (VAS) at baseline, and 15 and 30 min after intervention. Baseline pain score and demographic characteristics did not significantly different between the groups. After 30 min the pain score significantly reduced in both groups. While, at 15 and 30 min, mean pain score did not show statistically significant differences. Our findings indicated that Magnesium sulphate did not influence renal colic pain relief.

Citations

Oct 26, 2020·International Journal of Clinical Practice·Muhammed Enes AydinAli Ahiskalioglu
May 1, 2021·Nutrients·Véronique MorelGisèle Pickering
Jan 22, 2021·CNS & Neurological Disorders Drug Targets·Katarina S VujovićMilica Prostran
Jan 29, 2022·Postgraduate Medicine·Hassan SoleimanpourKavous Shahsavarinia

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