Comparisons among the complete genomes of four betanodavirus genotypes

Diseases of Aquatic Organisms
Yasushi Okinaka, Toshihiro Nakai

Abstract

Betanodaviruses, the causative agents of viral nervous necrosis in marine fish, have bipartite positive-sense RNA genomes and have been classified (based on analysis of RNA2 sequences) into 4 genotypes: tiger puffer nervous necrosis virus (TPNNV), barfin flounder nervous necrosis virus (BFNNV), striped jack nervous necrosis virus (SJNNV), and redspotted grouper nervous necrosis virus (RGNNV). Full-length genomes of TPNNV and BFNNV were sequenced for the first time in this study. Their sequence data and those of SJNNV and RGNNV retrieved from GenBank were compared in order to investigate the relationships among the 4 genotypes. Between TPNNV and BFNNV, sequence identities were relatively high in RNA1 and encoded Protein A, but were not significantly high in RNA2 or the coat protein (CP). Similarly, between BFNNV and RGNNV, the amino acid sequences of CP were highly similar, but identities of RNA1, RNA2, and Protein A sequences were not especially high. Furthermore, multiple alignment data of the 4 genotypes of RNA2 sequences revealed that the TPNNV and SJNNV sequences have the same sizes of gaps and extra sequences at the same positions. Collectively, these apparent contradictions in sequence identity suggest that betanodavirus ...Continue Reading

Citations

Jun 29, 2010·Archives of Virology·Naomi HataToshihiro Nakai
Jul 14, 2010·Virology Journal·Kei AdachiYasushi Okinaka
Aug 7, 2013·Developmental and Comparative Immunology·Young-Mao ChenTzong-Yueh Chen
Sep 17, 2016·Journal of Fish Diseases·Q K DoanF Allal
Nov 5, 2011·Veterinary Microbiology·Julian Ransangan, Benny Obrain Manin
Jul 22, 2016·PloS One·Valentina PanzarinGiovanni Cattoli
Jan 30, 2019·Journal of Fish Diseases·Young Chul KimHyun Do Jeong
Feb 14, 2020·Pathogens·Isabel Bandín, Sandra Souto

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