Comparisons between electromagnetic and X-beam transit-time flow measurements for evaluating drug actions on cardiac output in the conscious dog

Journal of Pharmacological and Toxicological Methods
David M FlynnDelvin R Knight

Abstract

Cardiac output remains an important preclinical measurement for evaluating the cardiovascular effects of drugs. We evaluated the performance of the Triton Active Redirection Transit-Time, ART(2), which represents a new class of X-beam flow systems and compared it in vivo and in vitro to an electromagnetic flow (EMF) system for measuring large vessel flow. In vivo, simultaneous aortic flow measurements were obtained during alpha- and beta-adrenergic receptor stimulation in 5 conscious dogs instrumented with both ART(2) and EMF probes on their ascending aortas. In vitro, simultaneous measurements of volume flow using the ART(2), EMF, and timed-volume collection were made using a novel benchtop flow apparatus that ensured probe alignment and precise timed-volume flow measurements. Accuracy and sensitivity of both systems were assessed by recording flow measurements while varying rates, temperature and hematocrit. In vivo aortic flow measurements between ART(2) and EMF were closely correlated (linear regression r(2) values ranged from 0.84 to 0.99), with the ART(2) system recording lower flow values than the EMF. In vitro ART(2) flow rates were in excellent agreement with timed-volume flow, while EMF flow rates were lower (p<0.05) ...Continue Reading

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Citations

Oct 19, 2010·Journal of Animal Science·G J van EssenD J Duncker

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