Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone

American Journal of Ophthalmology
Chandrakumar BalaratnasingamDao-Yi Yu

Abstract

To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomography angiography (OCTA) for visualizing the deep retinal circulation. Validity analysis and laboratory investigation. Five normal human donor eyes (mean age 69.8 years) were perfusion-labeled with endothelial antibodies and the capillary networks of the perifovea were visualized using confocal scanning laser microscopy. Regions of the capillary-free zone along the retinal artery were imaged using OCTA in 16 normal subjects (age range 24-51 years). Then, 3 × 3-mm scans were acquired using the RTVue XR Avanti (ver. 2016.1.0.26; Optovue, Inc, Fremont, California, USA), PLEX Elite 9000 (ver. 1.5.0.15909; Zeiss Meditec, Inc, Dublin, California, USA), Heidelberg Spectralis OCT2 (Family acquisition module 6.7.21.0; Heidelberg Engineering, Heidelberg, Germany), and DRI-OCT Triton (Ver. 1.1.1; Topcon Corp, Tokyo, Japan). Images of the superficial plexus, deep vascular plexus, and a slab containing all vascular plexuses were generated using manufacturer-recommended default settings. Comparisons between histology and OCTA were performed. Histologic anal...Continue Reading

Citations

Aug 4, 2018·Investigative Ophthalmology & Visual Science·Peter L Nesper, Amani A Fawzi
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Kazuya MorinoAkitaka Tsujikawa
Oct 2, 2019·Clinical & Experimental Ophthalmology·José I Fernández-VigoJosé Á Fernández-Vigo
Apr 28, 2020·Investigative Ophthalmology & Visual Science·Dong AnChandrakumar Balaratnasingam
May 3, 2019·Investigative Ophthalmology & Visual Science·Edmund ArthurStephen A Burns
Dec 15, 2018·Investigative Ophthalmology & Visual Science·Shota YasukuraAkitaka Tsujikawa
Jul 19, 2019·Translational Vision Science & Technology·Akihiro IshibazawaNadia K Waheed
Aug 29, 2020·Translational Vision Science & Technology·Julian LoMarinko V Šarunić
Dec 15, 2020·Ophthalmology Retina·Dmitrii S MaltsevK Bailey Freund
Feb 2, 2021·Translational Vision Science & Technology·Paula K YuDao-Yi Yu
Apr 29, 2020·Ophthalmology Retina·Stanislao RizzoGianni Virgili
Aug 4, 2021·Scientific Reports·Edmund ArthurPeter J Snyder
Dec 31, 2021·Translational Vision Science & Technology·Kentaro KawaiAkitaka Tsujikawa

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