Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures

Scientific Reports
Md Nasir UddinChase R Figley

Abstract

Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and diffusion-based imaging can be used to characterize tissue microstructure. However, surprisingly few studies have examined the degree to which these MRI measures are related within and between various brain regions. Therefore, whole-brain MRI scans were acquired from 31 neurologically-healthy participants to empirically measure and compare myelin water fraction (MWF), T1w/T2w ratio, fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) in 25 bilateral (10 grey matter; 15 white matter) regions-of-interest (ROIs). Except for RD vs. T1w/T2w, MD vs. T1w/T2w, moderately significant to highly significant correlations (p < 0.001) were found between each of the other measures across all 25 brain structures [T1w/T2w vs. MWF (Pearson r = 0.33, Spearman ρ = 0.31), FA vs. MWF (r = 0.73, ρ = 0.75), FA vs. T1w/T2w (r = 0.25, ρ = 0.22), MD vs. AD (r = 0.57, ρ = 0.58), MD vs. RD (r = 0.64, ρ = 0.61), AD vs. MWF (r = 0.43, ρ = 0.36), RD vs. MWF (r = -0.49, ρ = -0.62), MD vs. MWF (r = -0.22, ρ = -0.29), RD vs. FA (r = -0.62, ρ = -0.75) and MD vs. FA (r = -0.22, ρ = -0.18)]. However, while all six MRI measures were cor...Continue Reading

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Citations

Jul 17, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Laura CacciaguerraMassimo Filippi
Jul 28, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hanwen LiuCornelia Laule
Feb 6, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jongho LeeSe-Hong Oh
Jul 29, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gian Franco PireddaTobias Kober
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Apr 16, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Graham CooperFriedemann Paul
Jun 27, 2021·NeuroImage·Andrea Mendez ColmenaresAgnieszka Z Burzynska
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Nov 10, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Salem HannounDominique Sappey-Marinier

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Software Mentioned

CATNAP
CATNAP ( Coregistration , Adjustment Tensor - solving
SS
ROIEditor Toolbox
SPM12
FSL brain extraction tool ( BET )
MATLAB
DiffeoMap Toolbox
SPSS
mcDESPOT

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