PMID: 8980700Dec 12, 1996Paper

Comparisons on chemically-induced mutagenicity among four bacterial strains, Salmonella typhimurium TA102 and TA2638, and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101: collaborative study I

Mutation Research
K WatanabeT Sasaki

Abstract

A collaborative study of chemically-induced mutagenicity was performed using the four bacterial strains Salmonella typhimurium TA102 and TA2638 and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101 in order to compare the specific spectrum of response to chemicals among the four strains and to determine the usefulness (sensitivity) of each strain. Twenty laboratories participated in this study. As the first step, 29 compounds were tested for mutagenicity using the plate incorporation method with or without metabolic activation. The compounds consisted of 12 chemicals judged previously positive only in E. coli WP2 uvrA/pKM101, 15 of their derivatives, and the 2 well-known mutagens hydrazine and formaldehyde. The strains and the chemicals were sent from a central source to each laboratory. The tests were performed in two laboratories per chemical. Concerning the result with each strain, the number of chemicals which showed mutagenic activity were 10, 7, 9 and 17 in TA102, TA2638, WP2/pKM101 and WP2 uvrA/pKM101, respectively. Among these 29 compounds tested, no qualitative difference in the response to chemicals among the four strains was observed with 17 compounds, being 12 negative chemicals and 5 positive chemicals. The remaining...Continue Reading

References

Jan 1, 1977·Mutation Research·R F Kimball
Apr 1, 1992·Mutation Research·R JungW Müller
Jul 1, 1988·Mutation Research·T H Ma, M M Harris
May 1, 1983·Mutation Research·D M Maron, B N Ames
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D E LevinB N Ames

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Citations

Oct 10, 2001·Progress in Lipid Research·R J HeathC O Rock
Aug 26, 1998·Toxicology·C S AulettaW R Richter
Sep 21, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yayoi HayasakiKazuhisa Furuhama
Mar 16, 2018·The Journal of Toxicological Sciences·Yu HaranosonoHideyuki Sakaki

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