PMID: 11908572Mar 23, 2002Paper

Compartment differences in knee cartilage volume in healthy adults

The Journal of Rheumatology
Flavia M CicuttiniPeter Ebeling

Abstract

It is unclear why there are compartmental differences in the risk of knee osteoarthritis (OA). We investigated whether there are compartment differences in the volume of knee cartilage in healthy persons and identified determinants of medial and lateral tibial cartilage volume. A total of 166 healthy persons (age range 21-79 yrs, 58% female) with clinically and structurally normal knees were examined. Thickness and volume were determined for the medial and lateral tibial articular cartilages by processing images acquired in the sagittal plane using T1 weighted fat saturated magnetic resonance imaging on an independent work station. In every subject, the lateral tibial cartilage was thicker than medial cartilage (mean 6.43 +/- SD 1.25 mm vs 4.49 +/- 0.81 mm; p < 0.001), and the volume of cartilage was greater (2.34 +/- 0.70 ml vs 1.82 +/- 0.56 ml; p < 0.001). This effect persisted when values for men and women were analyzed separately. Both medial and lateral tibial cartilage volume and thickness were greater in men compared to women, independent of body mass index and bone size. The reduction in medial and lateral tibial cartilage volume and thickness was inversely related to the current level of physical activity. This study s...Continue Reading

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