Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms

Synapse
Paul Cumming, Albert Gjedde

Abstract

The trapping of decarboxylation products of radiolabelled dopa analogs in living human brain occurs as a function of the activity of dopa decarboxylase. This enzyme is now understood to regulate, with tyrosine hydroxylase, cerebral dopamine synthesis. Influx into brain of dopa decarboxylase substrates such as 6-[18F]fluorodopa and beta-[11C]dopa measured by positron emission tomography can be analyzed by solution of linear differential equations, assuming irreversible trapping of the decarboxylated products in brain. The isolation of specific physiological steps in the pathway for catecholamine synthesis requires compartmental modelling of the observed dynamic time-activity curves in plasma and in brain. The several approaches to the compartmental modelling of the kinetics of labelled substrates of dopa decarboxylase are now systematically and critically reviewed. Labelled catechols are extensively metabolized by hepatic catechol-O-methyltransferase yielding brain-penetrating metabolites. The assumption of a fixed blood-brain permeability ratio for O-methyl-6-[18F]fluorodopa or O-methyl-beta-[11C]dopa to the parent compounds eliminates several parameters from compartmental models. However, catechol-O-methyltransferase activity ...Continue Reading

References

Nov 1, 1992·Neuroreport·F B WeihmullerJ F Marshall
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G L ChanT J Ruth
Feb 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·A LuxenR Wagner
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A GjeddeH Kuwabara
Jan 1, 1991·Journal of Neural Transmission. General Section·P HartvigB Långström
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J DoudetR M Cohen
Jan 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·B J SnowD B Calne
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W P MelegaJ R Barrio
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C HuangM E Phelps
Jun 15, 1990·Biochemical Pharmacology·W P MelegaJ R Barrio
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J ReithA Gjedde
Dec 1, 1990·Annals of Neurology·G V SawleR S Frackowiak
Dec 1, 1990·Journal of Neuroscience Research·J R BarrioM E Phelps
Jul 1, 1990·Annals of Neurology·M H BhattD B Calne
Oct 1, 1989·Annals of Neurology·W R MartinD B Calne
Apr 1, 1989·Journal of Medicinal Chemistry·R BäckströmS Kaakkola

❮ Previous
Next ❯

Citations

Jan 19, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Thorsten KienastAndreas Heinz
Feb 6, 2008·Annals of Nuclear Medicine·Yoko IkomaYuichi Kimura
Oct 10, 2002·Biological Psychiatry·Aki LaaksoJarmo Hietala
Jan 31, 2002·Neurophysiologie clinique = Clinical neurophysiology·S ThoboisE Broussolle
Feb 26, 2000·Acta Physiologica Scandinavica·T Flatmark
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·UNKNOWN European Federation of Neurological Societies Task Force
Oct 26, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R TorstensonB Långström
Nov 8, 2008·PloS One·Rocio G UrdinguioManel Esteller
Nov 18, 2015·Journal of Liposome Research·Peter HinowIan G Tucker
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshitaka KumakuraPaul Cumming
Nov 1, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christian LandvogtKurt Ullrich
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V SossiJ E Holden
Jun 11, 2008·Neurobiology of Aging·Yoshitaka KumakuraPaul Cumming
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V SossiA J Stoessl
Jan 5, 2011·CNS Neuroscience & Therapeutics·Nobumi MiyakeAnissa Abi-Dargham
May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Jun 1, 2005·Brain Research Bulletin·Flemming AndersenUNKNOWN DaNeX Study Group
Jun 7, 2005·Neuroscience Letters·Wadad HassounVincent Leviel
Dec 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Alexander Popkov, Bart De Spiegeleer
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshitaka KumakuraPaul Cumming
Aug 22, 2014·Journal of Medicinal Chemistry·Markus PielFrank Rösch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
S C HuangM E Phelps
Proceedings of the National Academy of Sciences of the United States of America
A GjeddeH Kuwabara
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Yoshitaka KumakuraPaul Cumming
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Paul CummingA Gjedde
© 2022 Meta ULC. All rights reserved