Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal.

Journal of Lipid Research
Robert J PawloskyNorman Salem

Abstract

The mechanism by which chronic ethanol consumption reduces concentrations of long chain polyunsaturated (LCP) fatty acids (FA) in tissues of humans was investigated in alcohol-dependent (AD) men during early withdrawal and to a well-matched control group by fitting the concentration-time curves of d(5)-labeled n-3 FA from plasma and liver, which originated from an oral dose of d(5)-linolenic acid (d(5)-18:3n-3) ethyl ester to a compartmental model. Blood sampled over 168 h and a liver specimen obtained 96 h after isotope administration were analyzed for d(5)-18:3n-3, d(5)-20:5n-3, d(5)-22:5n-3, and d(5)-22:6n-3. Plasma 20:5n-3 and 22:5n-3 were lower in AD subjects, compared with controls (20:5n-3: -50%, 22:5n-3: -34%). Increased amounts of d(5)-18:3n-3 were directed toward synthesis of d(5)-20:5n-3 in AD subjects (P < .05). However, this effect was offset by larger amounts of 20:5n-3 lost from plasma (control: 2.0 vs. AD: 4.2 mg d(-1)). In livers of AD subjects, more d(5)-18:3n-3 and d(5)-22:5n-3 were utilized for synthesis of d(5)-20:5n-3 (+200%) and d(5)-22:6n-3 (+210%), respectively, than was predicted from plasma kinetics. Although, the potential to utilize linolenic acid for synthesis of LCP FA was greater in AD subjects c...Continue Reading

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Citations

Feb 9, 2012·Bioscience, Biotechnology, and Biochemistry·Noriko Komatsuzaki, Jun Shima
Apr 17, 2009·The Journal of Nutritional Biochemistry·Ya C WangShih T Ding
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Jan 21, 2016·Nutrition & Metabolism·Christel BjörkJurga Laurencikiene
Mar 25, 2011·The American Journal of Clinical Nutrition·Norman Salem, Connye N Kuratko

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