PMID: 11327511May 1, 2001Paper

Compartmental model for aluminium biokinetics

Human & Experimental Toxicology
E NolteC Steinhausen

Abstract

An open compartmental model for describing aluminium biokinetics is presented with a central compartment consisting of transferrin- and citrate-bound aluminium in blood plasma and interstitial fluid, and three peripheral compartments for organs, muscles and bones and the gastro-intestinal tract. The rate constants describing the transport of aluminium are normalized to an estimated plasma volume and do not depend on the size of the individual. Effects due to changes in compartmental sizes or to transport characteristics are described. The model is applied to biokinetics studies of a volunteer after i.v. administration and of Sprague-Dawley rats with different iron status and with nephrectomization after p.o. administration of 26Al.

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Aug 20, 2009·Radiation Protection Dosimetry·Jutta Schimmelpfeng
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C SteinhausenMichael J L Alvarez-Brückmann
Aug 9, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Corinne Seng YueMarc Ghannoum
Jul 15, 2009·Biochimie·Emmanuel CurisSimone Bénazeth
Oct 12, 2018·Archives of Toxicology·Karin WeisserBrigitte Keller-Stanislawski
Mar 3, 2021·Regulatory Toxicology and Pharmacology : RTP·Devika PoddalgodaAndy Nong
Aug 15, 2021·Archives of Toxicology·Christoph HetheyWilhelm Huisinga

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